中山大学学报（医学科学版）2025，Vol.46Issue(5)：747-755,9.
铁死亡与高血压相关性研究进展
Research Progress on the Association Between Ferroptosis and Hypertension
摘要
Abstract
The relationship between iron and hypertension has emerged as a significant frontier in cardiovascular research in recent years.Ferroptosis,a newly identified iron-dependent form of regulated cell death,has been demonstrated to play a critical role in the onset and progression of numerous cardiovascular diseases and their related conditions.The core mechanisms of ferroptosis involve dysregulated iron metabolism,lipid peroxidation,and impairment of antioxidant systems,all of which contribute importantly to the pathophysiology of hypertension.Among these,imbalance in iron metabolism and lipid peroxidation are the key drivers of hypertension associated vascular injury,vascular remodeling,and target organ damage.This review systematically summarizes the molecular correlation between ferroptosis and hypertension,focusing on the pathological and physiological mechanisms of iron metabolism disorders and lipid peroxidation,and explores their potential roles in hypertensive pathology.Furthermore,it also analyzes the synergistic physiological and pathological effects for ferroptosis in hypertension.By elucidating the regulatory mechanisms ferroptosis,this work proposes novel perspectives and directions for the early diagnosis and treatment of hypertension,offering a theoretical basis for clinical application.Additionally,therapeutic strategies targeting ferroptosis including iron chelators,antioxidants,and ferroptosis inhibitors are discussed.The aim is to provide a comprehensive and reliable theoretical foundation for future research and to offer innovative ideas for the early diagnosis and intervention of hypertension.关键词
高血压/铁死亡/铁代谢/脂质过氧化/铁超载Key words
hypertension/ferroptosis/iron metabolism disorders/lipid peroxidation/iron overload分类
医药卫生引用本文复制引用
刘琪悦,刘丽军..铁死亡与高血压相关性研究进展[J].中山大学学报（医学科学版）,2025,46(5):747-755,9.基金项目
国家自然科学基金(U20A20395) （U20A20395）
西藏自治区基地与人才基金(XZ202401JD0031) （XZ202401JD0031）
