中国肿瘤生物治疗杂志2025，Vol.32Issue(9)：899-905,7.DOI:10.3872/j.issn.1007-385x.2025.09.001
免疫细胞治疗实体瘤:聚焦双特异性抗体武装T/NK细胞
Immune cell therapy for solid tumors:focus on bispecific antibody armed T/NK cells
摘要
Abstract
Adoptive cell therapy continues to drive innovation in cancer immunotherapy.Among the emerging approaches,bispecific antibody(BsAb)-armed T cell and NK cell(T/NK cell)technology leverages antibodies to specifically target tumor antigens and bridge immune effector cells,thereby endowing these cells with precise tumor-killing capabilities while overcoming the limitations of traditional therapeutic strategies.This technology is characterized by its high degree of standardization,controllable safety,and a short clinical translational cycle,demonstrating promising therapeutic potential in both solid tumors and hematologic malignancies.This article provides a comprehensive review of the advancements in chimeric antigen receptor-engineered T/NK cell(CAR-T/NK cell),tumor-infiltrating lymphocyte(TIL),and cytokine-induced memory-like NK cell(CIML NK)therapies.Particular emphasis is placed on the mechanisms of action,advantages,clinical progress,and emerging trends of BsAb-armed T/NK cell therapy.关键词
肿瘤/过继细胞治疗/免疫治疗/双特异性抗体/T细胞/NK细胞Key words
tumor/adoptive cell therapy/immunotherapy/bispecific antibody/T cell/NK cell分类
医药卫生引用本文复制引用
陈天然,刘宝瑞..免疫细胞治疗实体瘤:聚焦双特异性抗体武装T/NK细胞[J].中国肿瘤生物治疗杂志,2025,32(9):899-905,7.基金项目
"十四五"江苏省医学重点学科(No.ZDXK202233) （No.ZDXK202233）
南京市肿瘤医学重点实验室项目 （）
国家中西医协同"旗舰"科室项目 （）
