肿瘤药学2025，Vol.15Issue(4)：491-499,9.DOI:10.3969/j.issn.2095-1264.2025.04.09
Piezo1与Nrf2/HO-1协同调控肿瘤细胞铁死亡机制的研究进展
Research progress on the synergistic regulation of tumor cell ferroptosis by Piezo1 and Nrf2/HO-1
摘要
Abstract
Ferroptosis plays a dual role(promoting and suppressing cancer)in tumorigenesis and therapy resistance,and elucidating its regulatory mechanisms while exploring its therapeutic potential holds significant clinical value.The Piezo1 channel and the Nrf2/HO-1 pathway provide new perspectives for ferroptosis regulation.As a mechanosensitive ion channel,Piezo1 dynamically regulates iron metabolism through calcium signaling,exhibiting biomechanical microenviron-ment-dependent effects.The Nrf2/HO-1 pathway,on the other hand,confers ferroptosis resistance in tumor cells by regu-lating antioxidant enzyme expression.Their interaction reveals a complex regulatory network of ferroptosis and offers novel molecular targets for cancer treatment.In-depth research on ferroptosis mechanisms has advanced related therapeutic strat-egies,and traditional Chinese medicine(TCM)has demonstrated unique advantages in modulating ferroptosis pathways.This review will summarize the regulatory mechanisms of ferroptosis,the roles of the Piezo1 channel and Nrf2/HO-1 path-way,and discuss combined targeting strategies as well as the potential application of TCM-based interventions.关键词
铁死亡/Piezo1/Nrf2/HO-1通路/肿瘤治疗Key words
Ferroptosis/Piezo1/Nrf2/HO-1 pathway/Cancer therapy分类
医药卫生引用本文复制引用
许林莉,杜婷婷,肖静..Piezo1与Nrf2/HO-1协同调控肿瘤细胞铁死亡机制的研究进展[J].肿瘤药学,2025,15(4):491-499,9.基金项目
国家自然科学基金项目(82374504). （82374504）
