首页|期刊导航|Journal of Biomedical Research|Bidirectional Mendelian randomization and mediation analysis of million-scale data reveal causal relationships between thyroid-related phenotypes,smoking,and lung cancer

Bidirectional Mendelian randomization and mediation analysis of million-scale data reveal causal relationships between thyroid-related phenotypes,smoking,and lung cancer

Xiang Wang Xuan Wang Mengsheng Zhao Lijuan Lin Yi Li Ning Xie Yanru Wang Aoxuan Wang Xiaowen Xu Can Ju Qiuyuan Chen Jiajin Chen Ruili Hou Zhongwen Zhang David C.Christiani Feng Chen Yongyue Wei Ruyang Zhang

Journal of Biomedical Research2025，Vol.39Issue(5)：P.441-451,I0001-I0023,34.

Journal of Biomedical Research2025，Vol.39Issue(5)：P.441-451,I0001-I0023,34.DOI:10.7555/JBR.38.20240421

Bidirectional Mendelian randomization and mediation analysis of million-scale data reveal causal relationships between thyroid-related phenotypes,smoking,and lung cancer

Xiang Wang ¹Xuan Wang ²Mengsheng Zhao ²Lijuan Lin ²Yi Li ³Ning Xie ²Yanru Wang ²Aoxuan Wang ²Xiaowen Xu ²Can Ju ²Qiuyuan Chen ²Jiajin Chen ²Ruili Hou ²Zhongwen Zhang ²David C.Christiani ⁴Feng Chen ¹Yongyue Wei ⁵Ruyang Zhang⁶

作者信息

1. Department of Biostatistics,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China China International Cooperation Center for Environment and Human Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China Jiangsu Key Lab of Cancer Biomarkers,Prevention and Treatment,Cancer Center,Collaborative Innovation Center for Cancer Personalized Medicine,Nanjing Medical University,Nanjing,Jiangsu 211166,China
2. Department of Biostatistics,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China
3. Department of Biostatistics,University of Michigan,Ann Arbor,MI 48109,USA
4. Pulmonary and Critical Care Division,Department of Medicine,Massachusetts General Hospital and Harvard Medical School,Boston,MA 02114,USA Department of Environmental Health,Harvard T.H.Chan School of Public Health,Boston,MA 02115,USA
5. Department of Biostatistics,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China Center for Public Health and Epidemic Preparedness&Response,Peking University,Beijing 100191,China
6. Department of Biostatistics,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China China International Cooperation Center for Environment and Human Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China Changzhou Medical Center,Nanjing Medical University,Changzhou,Jiangsu 213164,China.
折叠

摘要

关键词

hypothyroidism/hyperthyroidism/lung neoplasms/smoking/causality/Mendelian randomization analysis

分类

医药卫生

引用本文复制引用

Xiang Wang,Xuan Wang,Mengsheng Zhao,Lijuan Lin,Yi Li,Ning Xie,Yanru Wang,Aoxuan Wang,Xiaowen Xu,Can Ju,Qiuyuan Chen,Jiajin Chen,Ruili Hou,Zhongwen Zhang,David C.Christiani,Feng Chen,Yongyue Wei,Ruyang Zhang..Bidirectional Mendelian randomization and mediation analysis of million-scale data reveal causal relationships between thyroid-related phenotypes,smoking,and lung cancer[J].Journal of Biomedical Research,2025,39(5):P.441-451,I0001-I0023,34.

基金项目

funded by the National Natural Science Foundation of China(Grant Nos.82220108002 to F.C.,82273737 to R.Z.,82473728 to Y.W.) （Grant Nos.82220108002 to F.C.,82273737 to R.Z.,82473728 to Y.W.）

the US National Institutes of Health(Grant Nos.CA209414,HL060710,ES000002 to D.C.C. （）

CA209414,CA249096 to Y.L.) （）

the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).R.Z.was partially supported by the Qing Lan Project of the Higher Education Institutions of Jiangsu Province and the Outstanding Young-Level Academic Leadership Training Program of Nanjing Medical University. （PAPD）

Journal of Biomedical Research

ISSN：1674-8301

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