Role of polyphenols in epilepsy:from the perspective of gut microbiotaOA
Epilepsy is a devastating neurological condition that affects over 70 million people worldwide.Apart from idiopathic epilepsy,numerous diseases have been reported to cause secondary epilepsy.Polyphenols,ubiquitously existing in fruits and vegetables,has become a promising neuroprotective candidate against multiple neurological abnormalities due to its interplay with gut microbiome composed of the bacterial population in gastrointestinal system.This bioactive compound is also being tested for the management of epileptogenesis.However,there is still insufficient evidence from mechanistic studies to demonstrate the causal relationship between anti-epileptic effect of polyphenols and microbial alteration.In this review,we provide the brief overview of epilepsy,polyphenols and gut microbiota.We then analysis the association of polyphenols and gut microbiota particularly in the epilepsy and symptomatic seizures-induced by epilepsy related disorders.We also discuss the possibility for the combined application with probiotics to improve the bioavailability and bioaccessibility of polyphenols for expanding its anti-epileptic function.We finally summarize the therapeutic potential of anti-seizure polyphenols through affecting gut microbiome,and propose that the anti-epileptic effect of polyphenols may be tightly relevant to intestinal bacterial flora for overcoming epilepsy and its comorbidities simultaneously.Therefore,the dietary polyphenols targeting specific bacteria may achieve the outcome of‘one stone,two birds’.
Xiaoxue Xu;Jian Shi;Guiyang Cai;Chao Ma;Wuyang Wang;Rui Feng;Tomasz Boczek;Yinsi Tang;Zhenwei He;Feng Guo
Department of Pharmaceutical Toxicology,School of Pharmacy,China Medical University,Shenyang 110122,China Department of Neurology,The First Hospital of China Medical University,Shenyang 110001,ChinaDepartment of Pharmaceutical Toxicology,School of Pharmacy,China Medical University,Shenyang 110122,China Department of Pharmacy,The Fourth Affiliated Hospital of China Medical University,Shenyang 110032,ChinaDepartment of Obstetrics and Gynecology,Shengjing Hospital of China Medical University,Shenyang 110004,ChinaKey Laboratory of Structure-Based Drug Design&Discovery of Ministry of Education,School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016,ChinaJiangsu Province Key Laboratory of Anesthesiology,Xuzhou Medical University,Xuzhou 221002,ChinaDepartment of Pharmaceutical Toxicology,School of Pharmacy,China Medical University,Shenyang 110122,ChinaDepartment of Molecular Neurochemistry,Medical University of Lodz,Lodz 92215,PolandDepartment of Gastroenterology,The Fourth Affiliated Hospital of China Medical University,Shenyang 110032,ChinaDepartment of Neurology,The Fourth Affiliated Hospital of China Medical University,Shenyang 110032,ChinaDepartment of Pharmaceutical Toxicology,School of Pharmacy,China Medical University,Shenyang 110122,China Department of Pharmacy,The Fourth Affiliated Hospital of China Medical University,Shenyang 110032,China
临床医学
EpilepsyPolyphenolsGut microbiotaBioavailabilityBioaccessibility
《Food Science and Human Wellness》 2025 (8)
P.2988-3009,22
supported by the National Natural Science Foundation Committee of China(81971212,81601129)Shenyang Young and Middle-aged Technological Innovation Talent Support Program(RC210268)Liaoning Province Natural Science Foundation(2023-MS-153).
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