中医药临床杂志2025，Vol.37Issue(9)：1701-1705,5.DOI:10.16448/j.cjtcm.2025.0904
基于"三本二统"论及线粒体能量代谢障碍探讨肺癌癌因性疲乏机制
Mechanisms of Cancer-related Fatigue in Lung Cancer based on the"Three Principles and Two Units"Theory and Mitochondrial Energy Metabolism Disorders
摘要
Abstract
Cancer-related fatigue is a common complication of lung cancer,occurring most frequently during treat-ment and during the metastatic stage.It significantly reduces patients' quality of life and hinders treatment progress.Research suggests that the lung,spleen,and kidney,three organs,are key mechanisms underlying cancer-related fa-tigue,according to the"Three Roots and Two Systems"theory.Current research has found a close link between mito-chondrial energy metabolism disorders and the onset of cancer-related fatigue in lung cancer.In Traditional Chinese Medicine,dysfunctional function of the three organs-lung failure to descend,spleen failure to transport,and kidney failure to nourish essence-all impacts mitochondrial energy metabolism.Therapies targeting the principles of"clearing the lungs and protecting the lungs,""tonifying the middle and regulating the middle,"and"nourishing the kidneys and warming the Yang"can alleviate symptoms of cancer-related fatigue and improve mitochondrial energy metabolism.Therefore,this article explores the mechanisms underlying cancer-related fatigue in lung cancer based on the"Three Roots and Two Systems"theory and mitochondrial energy metabolism disorders,providing therapeutic strategies for treating cancer-related fatigue.关键词
三本二统/线粒体/癌因性疲乏/肺癌Key words
Three Roots and Two Systems/Mitochondria/Cancer-related fatigue/Lung cancer分类
医药卫生引用本文复制引用
李梦茜,李山山,齐琳芳,杨水苗,余雪汝,李晓丹..基于"三本二统"论及线粒体能量代谢障碍探讨肺癌癌因性疲乏机制[J].中医药临床杂志,2025,37(9):1701-1705,5.基金项目
国家自然科学基金资助项目(8210152432) （8210152432）
天津市卫生健康委员会中医中西医结合科研课题(2025186) （2025186）
