北京大学学报（医学版）2025，Vol.57Issue(5)：841-846,6.DOI:10.19723/j.issn.1671-167X.2025.05.005
基于微环境和干细胞调控的牙周组织再生关键技术的建立与应用
Establishment and application of key technologies for periodontal tissue regeneration based on microenvironment and stem cell regulation
摘要
Abstract
The prevalence of periodontitis in China is as high as 74.2％,making it the leading cause of tooth loss in adults and severely impacting both oral and overall health.The treatment of periodontitis and periodontal tissue regeneration are global challenges of significant concern.GE Shaohua's group at School and Hospital of Stomatology,Shandong University has focused on the key scientific issue of"re-modeling the periodontal inflammatory microenvironment and optimizing tissue repair and regeneration".They have elucidated the mechanisms underlying the persistence of periodontitis,developed bioactive ma-terials to enhance stem cell regenerative properties,and constructed a series of guided tissue regeneration barrier membranes to promote periodontal tissue repair,leading to the establishment of a comprehensive technology system for the treatment of periodontitis.Specific achievements and progress include:(1)Elucidating the mechanism by which key periodontal pathogens evade antimicrobial autophagy,leading to inflammatory damage;developing intelligent antimicrobial hydrogels and nanosystems,and creating metal-polyphenol network microsphere capsules to reshape the periodontal inflammatory microenviron-ment;(2)Explaining the mechanisms by which nanomaterial structures and electroactive interfaces regu-late stem cell behavior,developing optimized nanostructures and electroactive biomaterials,thereby effec-tively enhancing the regenerative repair capabilities of stem cells;(3)Creating a series of biphasic heterogeneous barrier membranes,refining guided tissue regeneration and in situ tissue engineering techniques,stimulating the body's intrinsic repair potential,and synergistically promoting the structural regeneration and functional reconstruction of periodontal tissues.The research outcomes of the group have innovated the fundamental theories of periodontal tissue regeneration,broken through foreign technologi-cal barriers and patent blockades,established a cascade repair strategy for periodontal regeneration,and enhanced China's core competitiveness in the field of periodontal tissue regeneration.关键词
牙周炎/微环境/干细胞/生物活性材料/牙周组织再生Key words
Periodontitis/Microenvironment/Stem cells/Bioactive materials/Periodontal tissue regeneration分类
医药卫生引用本文复制引用
马保金,商玲玲,葛少华,李建华,桑元华,于洋,仇吉川,邵金龙,李凯,刘世岳,杜密..基于微环境和干细胞调控的牙周组织再生关键技术的建立与应用[J].北京大学学报（医学版）,2025,57(5):841-846,6.基金项目
国家自然科学基金(82320108004、81873716、81670993、81901010、81901009、82471030、82470981)、国家(海外)优秀青年基金项目、国家临床重点专科(牙周病学)建设项目、山东省泰山学者工程项目(tstp20250510)Supported by the National Natural Science Foundation of China(82320108004,81873716,81670993,81901010,81901009,82471030,82470981),Excellent Young Scholars Fund(Overseas)of the National Natural Science Foundation of China,National Clinical Key Specialty(Periodontology)Construction Project,Construction Engineering Special Fund of"Taishan Scholars"of Shandong Province(tstp20250510). （82320108004、81873716、81670993、81901010、81901009、82471030、82470981）
