北京大学学报（医学版）2025，Vol.57Issue(5)：859-863,5.DOI:10.19723/j.issn.1671-167X.2025.05.008
唾液微生态在口腔及全身疾病早期防治中的应用
Application of salivary micro-ecosystem in early prevention and control of oral and systemic diseases
摘要
Abstract
Saliva is an important body fluid in the oral cavity containing lots of biomarkers,whose in-herent micro-ecosystem holds significant value for early diagnosis and monitoring of oral diseases.Simul-taneously,saliva has particular advantages,such as ease of sampling,painless and non-invasive collec-tion,and suitability for repeated sampling,making it highly appropriate for surveillance and follow-up of diseases.In a series of studies conducted by the research group for preventive dentistry in Peking Univer-sity School and Hospital of Stomatology,we compared different segments of saliva and those samples col-lected via different sampling methods using proteomic/peptidomic and microbiomic technologies to explore the stability of saliva samples.Besides,the significance of applying representative salivary biomarkers in early prevention and control of representative oral diseases(e.g.dental caries,periodontal diseases)and systemic conditions(e.g.type 2 diabetes mellitus,chronic kidney disease)was confirmed as well.关键词
唾液/微生态系统/多组学/生物学标志物/早期诊断Key words
Saliva/Micro-ecosystem/Multiomics/Biomarkers/Early diagnosis分类
医药卫生引用本文复制引用
孙翔宇,袁超,周芯竹,刁婧,郑树国..唾液微生态在口腔及全身疾病早期防治中的应用[J].北京大学学报（医学版）,2025,57(5):859-863,5.基金项目
国家重点研发计划(2022YFA1206100、2022YFE0118300)、国家自然科学基金(81801037)、首都卫生发展科研专项(首发2022-2G-4105)Supported by the National Key R&D Program of China(2022YFA1206100,2022YFE0118300),the National Natural Science Foundation of China(81801037)and the Capital's Funds for Health Improvement and Research(CFH2022-2G-4105) （2022YFA1206100、2022YFE0118300）
