川北医学院学报2025，Vol.40Issue(10)：1259-1262,4.DOI:10.3969/j.issn.1005-3697.2025.10.008
抗VEGF药物治疗渗出型老年性黄斑变性疗效及其对眼部血流动力学、OCT参数的影响
Efficacy of anti-VEGF drugs on exudative age-related macular degenera-tion and influence on ocular hemodynamics and OCT parameters
摘要
Abstract
Objective:To investigate the application effect of anti-vascular endothelial growth factor(VEGF)drugs in the treatment of exudative age-related macular degeneration.Methods:The clinical data of 110 patients with monocular exudative age-related macular degeneration were retrospectively analyzed.According to different medications,they were divided into con-bercept group(n=57,intravitreal injection of conbercept)and ranibizumab group(n=53,intravitreal injection of ranibizum-ab).The efficacy,ocular hemodynamics,OCT parameters and complications were compared between the two groups.Results:The total effective rate of treatment was 98.25%in conbercept group,which was higher than 88.68%in ranibizumab group(P<0.05).Compared with ranibizumab group,the PSV and EDV of central retinal artery and ocular artery and blood flow density of choroidal capillary layer in conbercept group were higher after treatment(P<0.05).The central macular thickness was thinner in conbercept group than that in ranibizumab group after treatment(P<0.05).There was no statistical difference in the total incidence rate of complications between groups(P>0.05).Conclusion:Anti-VEGF drugs can effectively treat exu-dative age-related macular degeneration.Conbercept has better efficacy,and it can better improve the ocular hemodynamics,cen-tral macular thickness and choroidal capillary layer blood flow density,with safety.关键词
抗血管内皮生长因子药物/渗出型/年龄相关性黄斑变性/光学相干断层扫描血管成像Key words
Anti-vascular endothelial growth factor drugs/Exudative type/Age-related macular degeneration/Optical co-herence tomography分类
医药卫生引用本文复制引用
白艳,王峰,张勤,刘君..抗VEGF药物治疗渗出型老年性黄斑变性疗效及其对眼部血流动力学、OCT参数的影响[J].川北医学院学报,2025,40(10):1259-1262,4.基金项目
山西省卫生健康委科研计划课题(2021010) （2021010）
