川北医学院学报2025，Vol.40Issue(10)：1276-1279,4.DOI:10.3969/j.issn.1005-3697.2025.10.012
美托洛尔联合阿司匹林对急性心肌梗死经皮冠状动脉介入治疗患者心肌挽救及早期主要心血管不良事件发生的影响
Effects of metoprolol combined with aspirin on myocardial salvage and early major adverse cardiovascular events in patients with acute myocar-dial infarction percutaneous coronary intervention
摘要
Abstract
Objective:To investigate the effects of metoprolol combined with aspirin on myocardial salvage and early major adverse cardiovascular events(MACE)in patients undergoing percutaneous coronary intervention(PCI)for acute myocardial infarction.Methods:120 patients with acute myocardial infarction were selected and divided into a control group and an observa-tion group based on the order of admission,with 60 cases in each group.Both groups received PCI treatment,the control group was given aspirin orally,while the observation group was given metoprolol combined with aspirin oral administration.The echo-cardiographic indicators,serum brain natriuretic peptide(BNP)and troponin I(cTnI)levels,coagulation function indicators[prothrombin time(PT),activated partial thromboplastin time(APTT)],myocardial salvage status,and MACE occurrence within 30 days after PCI were compared before and after treatment in both groups.Results:After treatment,the left ventricular ejection fraction(LVEF)of both groups increased,while the left ventricular end-diastolic diameter(LVEDD)and left ventricu-lar end-systolic diameter(LVESD)decreased(P<0.05).The improvement in these indicators was more significant in the ob-servation group compared to the control group(P<0.05).After treatment,the serum BNP and cTnI levels in both groups de-creased,with the observation group showed lower levels than the control group(P<0.05).After treatment,the prothrombin time(PT)and activated partial thromboplastin time(APTT)in both groups were prolonged(P<0.05),with the observation group had a longer APTT than the control group(P<0.05).There was no significant difference in the volume of edematous myocardium between the two groups(P>0.05),but the salvageable myocardial volume and microscopically visible myocardial salvage index(MSI)in the observation group were greater than those in the control group(P<0.05).The early MACE inci-dence in the observation group was lower than that in the control group(P<0.05).Conclusion:Metoprolol combined with aspi-rin can effectively improve the myocardial salvage effect in patients undergoing PCI for acute myocardial infarction,reduce the early MACE incidence,and positively impact patient outcomes.关键词
急性心肌梗死/经皮冠状动脉介入/美托洛尔/阿司匹林/心肌挽救/主要心血管不良事件Key words
Acute myocardial infarction/Percutaneous coronary intervention/Metoprolol/Aspirin/Myocardial salvage/Major adverse cardiovascular events分类
医药卫生引用本文复制引用
桑建,隋利军..美托洛尔联合阿司匹林对急性心肌梗死经皮冠状动脉介入治疗患者心肌挽救及早期主要心血管不良事件发生的影响[J].川北医学院学报,2025,40(10):1276-1279,4.基金项目
江苏省无锡市科学技术协会软科学研究项目(KX-24-C035) （KX-24-C035）
