磁共振成像2025，Vol.16Issue(9)：8-14,27,8.DOI:10.12015/issn.1674-8034.2025.09.002
经皮耳迷走神经刺激调节经前期综合征大脑三网络模型功能连接的fMRI研究
Modulation of triple network connectivity in premenstrual syndrome by transcutaneous auricular vagus nerve stimulation:A fMRI study
摘要
Abstract
Objective:To investigate the immediate effects of transcutaneous auricular vagus nerve stimulation(taVNS)at different stimulation frequencies on abnormal functional connectivity(FC)and functional network connectivity(FNC)within the triple network model(TNM)in patients with premenstrual syndrome(PMS).Materials and Methods:This single-center,prospective study enrolled 56 patients with PMS and 67 healthy controls(HC).All participants underwent resting-state functional magnetic resonance imaging(rs-fMRI)and clinical assessments before and after taVNS.Independent component analysis(ICA)was used to extract FC and FNC of key brain networks within TNM,including the default mode network(DMN),executive control network(ECN),and salience network(SN).Based on the TNM network templates,two-sample t-tests were conducted to compare differences in FC and FNC between the PMS and HC groups,and correlation analyses were performed between the altered brain regions and clinical psychological scale scores.Furthermore,paired-sample t-tests were used to evaluate the modulatory effects of taVNS at different stimulation frequencies(2 Hz,25 Hz,and sham stimulation)on abnormal FC and FNC within the TNM in PMS patients.Results:Compared to HC,patients with PMS exhibited increased FC within the SN,specifically in the left inferior frontal gyrus(LIFG),insula,and superior temporal gyrus(STG),which positively correlated with emotional,physical,cognitive,and behavioral symptoms(r=0.377-0.403,P<0.05,FDR corrected).Altered FNC was also observed,with decreased SN-right ECN(rECN),increased SN-dorsal DMN(dDMN)and dDMN-rECN,the latter negatively associated with physical scores(r=-0.18,P<0.05,FDR corrected).Following taVNS,both 2 Hz and 25 Hz significantly reduced FC within the SN in PMS patients(P<0.05,FDR corrected).Specifically,2 Hz mainly modulated the prefrontal cortex,LIFG,insula,and STG,while 25 Hz predominantly affected the STG.After sham stimulation(st-taVNS),no significant FC changes were observed within the SN in PMS patients.However,25 Hz-taVNS led to a further decrease in FNC between the SN and rECN(P<0.05,FDR corrected),whereas no significant changes were observed in the HC group.Conclusions:TaVNS modulates abnormal FC and FNC within TNM-related brain networks in PMS patients.The immediate modulation effects vary by stimulation frequency,indicating the potential need for personalized frequency selection based on individual symptoms.关键词
经前期综合征/经皮耳迷走神经刺激/磁共振成像/功能连接/功能网络连接Key words
premenstrual syndrome/transcutaneous auricular vagus nerve stimulation/magnetic resonance imaging/functional connectivity/functional network connectivity分类
医药卫生引用本文复制引用
林士洹,陀思静,吴月娟,刘珍,邓德茂,张妍,赖茵圻,张清萍,陈娅,赖梓焱,区媛媛,李姗珊,周慧..经皮耳迷走神经刺激调节经前期综合征大脑三网络模型功能连接的fMRI研究[J].磁共振成像,2025,16(9):8-14,27,8.基金项目
National Natural Science Foundation of China(No.82060315) （No.82060315）
Guangxi Key Research and Development Program(No.Gui Ke AB22080053,Gui Ke AB25069037). 国家自然科学基金项目(编号:82060315) （No.Gui Ke AB22080053,Gui Ke AB25069037）
广西重点研究发展项目(编号:桂科AB22080053、桂科AB25069037) （编号:桂科AB22080053、桂科AB25069037）
