磁共振成像2025，Vol.16Issue(9)：15-21,7.DOI:10.12015/issn.1674-8034.2025.09.003
3D-ASL技术在神经精神性狼疮患者脑血流灌注中的应用研究
Application of 3D-ASL in assessing cerebral blood flow perfusion in patients with neuropsychiatric systemic lupus erythematosus
摘要
Abstract
Objective:To investigate the correlation between changes in cerebral perfusion patterns and serum immunological markers as well as cognitive assessments in patients with neuropsychiatric systemic lupus erythematosus(NPSLE)using three-dimensional arterial spin labeling(3D-ASL)technology,and to explore the pathogenesis of NPSLE from an imaging perspective.Materials and Methods:Prospectively collected imaging,clinical serological,and cognitive assessment data from 37 NPSLE patients,52 non-neuropsychiatric systemic lupus erythematosus(non-NPSLE)patients,and 39 healthy controls(HC)were analyzed.Differences in cerebral perfusion patterns were compared,and correlation analyses were conducted between cerebral blood flow(CBF)values in differentially perfused brain regions of NPSLE patients and serum/cognitive indicators.Results:CBF differences revealed that the NPSLE group exhibited significantly higher CBF in the left middle temporal gyrus and left supramarginal gyrus compared to the non-NPSLE group(P<0.001).Compared to the HC group,the NPSLE group showed increased CBF in the aforementioned regions as well as decreased CBF in multiple brain areas,including the right superior frontal gyrus(P<0.001).Correlation analysis demonstrated that in NPSLE patients,CBF values in the left middle temporal gyrus were positively correlated with hemoglobin(r=0.392,P=0.037),red blood cell count(r=0.437,P=0.022),and visuospatial/executive function scores on the Montreal Cognitive Assessment(MoCA)(r=0.358,P=0.016),while negatively correlated with anxiety scale scores(r=-0.380,P=0.015).CBF values in the left supramarginal gyrus were positively correlated with hemoglobin(r=0.612,P=0.016),hematocrit(r=0.457,P=0.016),and complement 3(r=0.538,P=0.008),but negatively correlated with beck anxiety inventory(BAI)scores(r=-0.397,P=0.040).Conclusions:Patients with NPSLE have abnormal cerebral perfusion patterns.These changes may play a key role in the pathophysiological process of neuropsychiatric symptoms in patients with NPSLE and are involved in the occurrence and development of its pathological mechanism.关键词
神经精神狼疮/脑血流灌注/认知功能障碍/三维动脉自旋标记/磁共振成像Key words
neuropsychiatric systemic lupus erythematosus/cerebral blood flow/cognitive dysfunction/three-dimensional arterial spin labeling/magnetic resonance imaging分类
医药卫生引用本文复制引用
安宁,马悦,赵瑞婷,马雪英,乔鹏飞..3D-ASL技术在神经精神性狼疮患者脑血流灌注中的应用研究[J].磁共振成像,2025,16(9):15-21,7.基金项目
Inner Mongolia Autonomous Region Science and Technology Program(No.2023YFSH0014). 内蒙古自治区科技计划项目(编号:2023YFSH0014) （No.2023YFSH0014）
