磁共振成像2025，Vol.16Issue(9)：40-45,6.DOI:10.12015/issn.1674-8034.2025.09.007
水抑制酰胺质子转移加权成像抑制治疗后胶质瘤液性成分信号的可行性研究
The feasibility of fluid-suppressed amide proton transfer-weighted imaging in suppressing the fluid components of post-treatment gliomas
摘要
Abstract
Objective:To investigate the feasibility of fluid-suppressed amide proton transfer-weighted imaging(FS-APTw)in suppressing the fluid components of post-treatment gliomas.Materials and Methods:Fifty-nine patients with surgically and pathologically confirmed gliomas who received standard postoperative chemoradiotherapy were prospectively collected and underwent APTw and FS-APTw imaging.The APTw and FS-APTw maps were coregistered and fused with anatomical maps to extract APTw and FS-APTw values from fluid components,peri-lesion edema,and measurable enhancing regions of gliomas.Comparisons were made using the paired-samples t-test or Wilcoxon signed ranks test.Subgroup analyses were performed according to the characteristics of the fluid compartments on FLAIR and DWI images(Group 1,low signal on both FLAIR and DWI;Group 2,equal or high signal on FLAIR but low signal on DWI;Group 3,equal or high signal on FLAIR and high or mixed signals on DWI).The efficacy of fluid suppression among the three groups was compared using the Kruskal-Wallis test,followed by the post-hoc tests.Results:After the use of fluid suppression,the FS-APTw values of the fluid and edema compartments were significantly decreased,as compared to their corresponding APTw values(1.37%vs.1.67%,1.03%vs.1.14%)(both P<0.05).No significant difference was found in enhancing compartments(2.16%vs.2.22%,P=0.404).The subgroup analysis showed notable differences in the baseline APTw values of the fluid compartments across the three groups.Specifically,Group 2 and 3 exhibited significantly higher APTw values(3.80%and 1.85%,respectively)compared to Group 1(1.00%,P<0.05).After fluid suppression,a marked decrease in FS-APTw values was observed in the fluid compartments of all three groups,as compared to their respective APTw values(P<0.05 for all).Notably,the most pronounced reduction in APTw value was discerned in Group 2(-1.23%).Conclusions:FS-APTw can effectively suppress the APTw signals of fluid components in post-treatment gliomas,while maintaining the signals of solid tissues.This fluid suppression effect was particularly pronounced in fluid compartments with protein-rich liquid,shown as equal or high signal intensities on FLAIR and low on DWI.关键词
胶质瘤/水抑制/液性成分/酰胺质子转移加权成像/磁共振成像Key words
glioma/fluid suppression/fluid components/amide proton transfer weighted imaging/magnetic resonance imaging分类
医药卫生引用本文复制引用
侯静文,张墀,苏春秋,赵献策,曹远东,鲁珊珊..水抑制酰胺质子转移加权成像抑制治疗后胶质瘤液性成分信号的可行性研究[J].磁共振成像,2025,16(9):40-45,6.基金项目
National Natural Science Foundation of China(No.82171907). 国家自然科学基金项目(编号:82171907) （No.82171907）
