磁共振成像2025，Vol.16Issue(9)：53-59,7.DOI:10.12015/issn.1674-8034.2025.09.009
磁共振成像直方图分析预测生长激素型垂体神经内分泌肿瘤术后长期疗效的价值
The value of MRI histogram analysis in predicting the long-term therapeutic effect after surgery for growth hormone-secreting pituitary neuroendocrine tumors
摘要
Abstract
Objective:To explore the value of MRI histogram analysis in predicting the long-term efficacy of transsphenoidal neuroendoscopic surgery for growth hormone-secreting pituitary neuroendocrine tumors before and early after surgery.Materials and Methods:A total of 43 patients with growth hormone-secreting pituitary neuroendocrine tumors from June 2021 to June 2023 were retrospectively included,among which 22 achieved remission and 21 did not.Clinical,pathological,and laboratory data were evaluated and recorded.Histogram parameters were extracted and calculated based on the T2WI sequence.The differences in histogram parameters combined with preoperative and early postoperative clinical semantic features between the long-term remission and non-remission groups were analyzed,and their diagnostic performance was evaluated.Results:In the preoperative clinical semantic characteristics between the two groups,statistically significant differences were observed in cavernous sinus invasion(χ2=5.495),acromegaly(χ2=4.240),preoperative growth hormone(GH)levels(Z=-2.821),and serum insulin-like growth factor-1(IGF-1)levels(t=-2.856)(all P<0.05).Among the early postoperative clinical semantic features,immediate postoperative GH(Z=-3.681)and IGF-1 levels(t=0.247)also demonstrated statistically significant differences(both P<0.05).Regarding histogram parameters,significant differences were found in area(t=-2.716)and kurtosis(Z=-2.332)(both P<0.05).The diagnostic performance of the model was evaluated using receiver operating characteristic(ROC)curve analysis and area under the curve(AUC).The predictive model incorporating MRI histogram parameters with preoperative and early postoperative clinical,pathological,and laboratory data exhibited optimal performance,achieving an AUC of 0.963.At a cutoff value of 0.447,the sensitivity and specificity were 95.2%and 86.4%,respectively.Conclusions:T2WI histogram parameters provide additional value in predicting the long-term efficacy of GH-PitNET postoperative outcomes.关键词
垂体神经内分泌肿瘤/磁共振成像/直方图分析/预测/疗效Key words
pituitary neuroendocrine tumor/magnetic resonance imaging/histogram analysis/prognosis/efficacy分类
医药卫生引用本文复制引用
屈瑞,董文洁,刘建莉..磁共振成像直方图分析预测生长激素型垂体神经内分泌肿瘤术后长期疗效的价值[J].磁共振成像,2025,16(9):53-59,7.基金项目
Outstanding Young Talents and Backbone Talents Project of Gansu Provincial Health Industry Scientific Research Plan(No.GSWSQN2023-04) （No.GSWSQN2023-04）
"Cuiying Graduate Mentor"Training Program of Lanzhou University Second Hospital(No.CYDSPY202003). 甘肃省卫生行业科研计划优秀青年人才和骨干人才项目(编号:GSWSQN2023-04) （No.CYDSPY202003）
兰州大学第二医院"萃英研究生导师"培养计划项目(编号:CYDSPY202003) （编号:CYDSPY202003）
