磁共振成像2025，Vol.16Issue(10)：7-13,7.DOI:10.12015/issn.1674-8034.2025.10.002
针刺"四关"穴对阿尔茨海默病患者海马亚区功能连接的影响
Effects of acupuncture at the Si Guan points on functional connectivity of hippocampal subregions in patients with Alzheimer's disease
摘要
Abstract
Objective:To assess the sustained effect of acupuncture at the Si Guan points on functional connectivity of hippocampal subregions in patients with Alzheimer's disease(AD)and normal controls(NC).Materials and Methods:Demographic data,neuropsychological assessments,and resting-state functional magnetic resonance imaging(fMRI)data were collected from 14 AD patients and 14 NCs matched by age,sex,and educational level at baseline.After the baseline MRI scan,acupuncture stimulation on the Si Guan points was performed for 3 minutes.Then,another 10 minutes of fMRI data were acquired after the needle was withdrawn.A dataset that included 100 healthy participants was also included to construct a reliable functional connectivity map of the hippocampal subregions.Regions of interest(ROIs)in the bilateral anterior hippocampus(aHPC)and posterior hippocampus(pHPC)were selected to assess the sustained effect of acupuncture on functional connectivity of hippocampal subregions in AD patients and NCs.Results:Resting-state functional connectivity analysis demonstrated that multiple brain regions,including the orbitofrontal cortex(OFC),parahippocampal gyrus(PHG),superior temporal gyrus(STG)and insula,showed increased functional connectivity with the hippocampal subregions in the AD group(all P<0.05)and decreased functional connectivity with the hippocampal subregions in the NC group after acupuncture compared to that at baseline(all P<0.05).However,superior frontal gyrus(SFG)showed decreased functional connectivity with the hippocampal subregions in the AD group(P<0.05)and increased functional connectivity with the hippocampal subregions in the NC group(P<0.01)after acupuncture compared to that at baseline.Acupuncture also specifically elicited increased functional connectivity between the aHPC and the medial frontal cortex(P<0.01)as well as decreased functional connectivity between the pHPC and the PHG(P<0.05)in the NC group.Additionally,functional connectivity between the aHPC and the OFC was positively correlated with neuropsychological scale scores in the AD group before acupuncture treatment(r=0.70,P=0.016).Conclusions:These findings confirm and extend previous studies suggesting that acupuncture at Si Guan points can exert bidirectional and benign regulatory effects on functional connectivity of hippocampal subregions in AD patients.关键词
阿尔茨海默病/静息态功能磁共振成像/磁共振成像/针刺/海马亚区Key words
Alzheimer's disease/resting-state functional magnetic resonance imaging/magnetic resonance imaging/acupuncture/hippocampal subfields分类
医药卫生引用本文复制引用
樊丽华,田欣,陈媛媛,魏伟,王志群,王军凯,周锋,郑运松..针刺"四关"穴对阿尔茨海默病患者海马亚区功能连接的影响[J].磁共振成像,2025,16(10):7-13,7.基金项目
2024 Shaanxi Provincial Key R&D Program(No.2024SF-YBXM-524) （No.2024SF-YBXM-524）
2023 Open Project of Shaanxi Provincial Key Laboratory of Acupuncture and Pharmacy Integration,Shaanxi University of Chinese Medicine(No.KF202320). 2024年度陕西省重点研发计划项目(编号:2024SF-YBXM-524) （No.KF202320）
2023年度陕西中医药大学陕西省针药结合重点实验室开放课题(编号:KF202320) （编号:KF202320）
