边缘型人格障碍患者的脑自发活动改变:一项基于rs-fMRI的激活似然估计Meta分析
Altered spontaneous brain activity in patients with borderline personality disorder:An activation likelihood estimation Meta-analysis of resting-state fMRI studies
摘要
Abstract
Objective:To investigate consistent alterations in spontaneous brain activity in patients with borderline personality disorder(BPD)using resting-state functional magnetic resonance imaging(rs-fMRI),in order to further explore the potential neurobiological mechanisms underlying BPD.Materials and Methods:Relevant literature published before May 8,2025,was systematically searched using amplitude of low-frequency fluctuation/fractional ALFF(ALFF/fALFF)and regional homogeneity(ReHo)analytical methods to assess changes in resting-state brain function in BPD patients.Based on strict inclusion and exclusion criteria,the activation likelihood estimation(ALE)method was used to integrate and analyze brain regions exhibiting aberrant spontaneous neural activity in BPD patients compared to healthy controls(HCs),using GingerALE 3.0.2 software.Results:A total of six studies met the inclusion criteria,involving 293 BPD patients and 197 HCs.By combining ALFF/fALFF and ReHo data,the results showed significantly increased spontaneous activity in the left lentiform nucleus,left parahippocampal gyrus,and bilateral cuneus in BPD patients compared to HCs(P<0.05).In contrast,decreased activity was observed in the right cuneus,right posterior cingulate cortex,left cingulate gyrus,left precuneus,left middle frontal gyrus,and left superior frontal gyrus(P<0.05).Conclusions:This ALE meta-analysis identified abnormal spontaneous brain activity across multiple brain regions in BPD patients,contributing to a deeper neuroimaging-based understanding of BPD and offering valuable insights for future clinical interventions.关键词
边缘型人格障碍/静息态功能磁共振成像/磁共振成像/激活似然估计/Meta分析/自发神经活动Key words
borderline personality disorder/resting-state functional magnetic resonance imaging/magnetic resonance imaging/activation likelihood estimation/Meta-analysis/spontaneous neural activity分类
医药卫生引用本文复制引用
舒燕萍,张琴,侯勇哲,李达..边缘型人格障碍患者的脑自发活动改变:一项基于rs-fMRI的激活似然估计Meta分析[J].磁共振成像,2025,16(10):14-20,7.基金项目
National Natural Science Foundation of China(No.82460282) （No.82460282）
Guizhou Provincial Science and Technology Program(No.Qiankehe Foundation MS[2025]025,Qiankehe Foundation ZK[2023]General 195) （No.Qiankehe Foundation MS[2025]025,Qiankehe Foundation ZK[2023]General 195）
High-level Innovative Talent Program of Guizhou Province(Thousand-Level Talent Project)(No.gzwjrs2022-013) （Thousand-Level Talent Project）
2025-2026 Guizhou Provincial Key Medical Discipline Construction Project Funding,issued by Guizhou Provincial Health Commission(No.Qiancaiyu[2025]No.1) （No.Qiancaiyu[2025]No.1）
Science and Technology Fund Project of Guizhou Provincial Health Commission(No.gzwkj2025-045). 国家自然科学基金项目(编号:82460282) （No.gzwkj2025-045）
贵州省科技计划项目(编号:黔科合基础MS[2025]025、黔科合基础ZK[2023]一般195) （编号:黔科合基础MS[2025]025、黔科合基础ZK[2023]一般195）
贵州省高层次创新型人才项目(千层次)(编号:gzwjrs2022-013) （千层次）
2025～2026年度贵州省卫生健康委省级医学重点学科建设项目经费项目(编号:黔财预[2025]1号) （编号:黔财预[2025]1号）
贵州省卫生健康委科学技术基金项目(编号:gzwkj2025-045) （编号:gzwkj2025-045）
