磁共振成像2025，Vol.16Issue(10)：21-27,7.DOI:10.12015/issn.1674-8034.2025.10.004
自动纤维定量技术在检测发作期无先兆偏头痛患者脑白质纤维束微结构节段性改变中的应用研究
Research on the application of automatic fiber quantification technique in detecting segmental alterations in cerebral white matter tracts in patients with migraine without aura in the ictal phase
摘要
Abstract
Objective:To explore segmental microstructural alterations of cerebral white matter tracts in patients with migraine without aura(MwoA)in the ictal phase using automatic fiber quantification(AFQ),and to analyze the relationship between these alterations and clinical symptoms.Materials and Methods:A total of 45 MwoA patients in the ictal phase(MwoA group)and 30 matched healthy controls(HC)were enrolled.Clinical data and MRI data were collected.AFQ technology was applied to analyze diffusion tensor imaging(DTI)data at both entire and nodal levels.Twenty white matter tracts across the brain were tracked,and 100 equidistant nodes were defined for each tract to calculate diffusion indices,including fractional anisotropy(FA),mean diffusivity(MD),axial diffusivity(AD),and radial diffusivity(RD).Two-sample t-tests were used to compare diffusion indices between groups,and partial correlation analysis was performed to assess the correlation between abnormal tract indices in the MwoA group and clinical scale scores.Results:Compared with the HC group,at the entire level,the MwoA group exhibited increased MD and RD in the forceps minor of the corpus callosum(CF minor)(FDR correction,all P<0.05).Nodal analysis revealed that the MwoA group exhibited decreased FA in the left inferior fronto-occipital fasciculus(IFOF),increased MD in the left thalamic radiation(TR),the CF minor,and the right IFOF,increased AD in the right IFOF,decreased AD in the left uncinate fasciculus(UF),and increased RD in the left TR and CF minor(FDR correction,all P<0.05).Additionally,the mean AD and MD values of the abnormal segments in the right IFOF were positively correlated with headache impact test scores(r=0.351,r=0.331,all P<0.05),while the mean AD value of the abnormal segments in the left UF was negatively correlated with migraine-specific quality of life questionnaire scores(r=-0.535,P<0.001).Conclusions:In the MwoA ictal period,patients exhibit segmental microstructural damage in multiple white matter fiber tracts.Segmental abnormalities in the right inferior fronto-occipital fasciculus and left uncinate fasciculus may be closely associated with the neuropathological mechanisms of MwoA in the ictal phase.关键词
无先兆偏头痛/发作期/磁共振成像/扩散张量成像/自动纤维定量Key words
migraine without aura/ictal phase/magnetic resonance imaging/diffusion tensor imaging/automatic fiber quantification分类
医药卫生引用本文复制引用
仇家敏,王心怡,翟长红,张赫,郭耀文,李倩,李青龙,崔应麟,王同明..自动纤维定量技术在检测发作期无先兆偏头痛患者脑白质纤维束微结构节段性改变中的应用研究[J].磁共振成像,2025,16(10):21-27,7.基金项目
Key Research and Development Project of Henan Province(No.221111310500). 河南省重点研发专项项目(编号:221111310500) （No.221111310500）
