磁共振成像2025，Vol.16Issue(10)：55-59,5.DOI:10.12015/issn.1674-8034.2025.10.009
DCE-MRI定量参数与肝外胆管癌病理分化程度及血管生成的相关性研究
A study on the correlation between quantitative parameters of DCE-MRI and the pathological grading and angiogenesis of extrahepatic cholangiocarcinoma
摘要
Abstract
Objective:To explore the correlation between quantitative perfusion parameters of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)and the pathological grade and angiogenesis of extrahepatic cholangiocarcinoma(ECCA).Materials and Methods:Fifty patients with ECCA underwent conventional MRI and DCE-MRI scans before surgery.The microvessel density(MVD)and vascular endothelial growth factor(VEGF)expression in postoperative specimens were detected by immunohistochemistry.The relationships between DCE-MRI quantitative parameters and pathological grade,MVD,and VEGF expression were analyzed.Results:Among the 50 patients with ECCA,15 cases were well differentiated,23 cases were moderately differentiated,and 12 cases were poorly differentiated.The volume transfer constant(Ktrans)and extracellular extravascular volume fraction(Ve)of ECCA patients were not correlated with pathological grade or VEGF expression(P>0.05).Ktrans was positively correlated with MVD(r=0.524,P<0.001),while the rate constant(Kep)and Ve were not related to MVD(P>0.05).Conclusions:The DCE-MRI parameter Ktrans is positively correlated with MVD,confirming its feasibility in non-invasively reflecting the angiogenesis of ECCA to a certain extent;however,since Kep and Ve values do not show a similar correlation,their efficacy in evaluating invasiveness and prognosis still needs to be further verified by prospective studies with larger samples.关键词
肝外胆管癌/肿瘤血管生成/动态对比增强磁共振成像/病理分化程度Key words
extrahepatic cholangiocarcinoma/tumor angiogenesis/dynamic contrast-enhanced magnetic resonance imaging/pathological grade分类
医药卫生引用本文复制引用
李双双,杨婷,孙西浚,李鹏辉,彭善凯,张莉..DCE-MRI定量参数与肝外胆管癌病理分化程度及血管生成的相关性研究[J].磁共振成像,2025,16(10):55-59,5.基金项目
Lanzhou City Innovation and Entrepreneurship Talent Project(No.2020-RC-74). 兰州市创新创业人才基金项目(编号:2020-RC-74) （No.2020-RC-74）
