大连工业大学学报2025，Vol.44Issue(5)：354-358,5.DOI:10.19670/j.cnki.dlgydxxb.2025.0507
氨甲环酸纳米胶囊的绿色制备及性能
Green preparation and performance of tranexamic acid nano-capsules
摘要
Abstract
The sodium alginate-gelatin-tranexamic acid nano-capsules were prepared by ultrasonic recondensation method.The effects of preparing conditions,e.g.,sodium alginate,gelatin and transminoic acid concentrations,temperature,pH value and coacervation time on the encapsulation rate of nano-capsules were also investigated via single factor experiment.The conditions for preparing tranexamic acid nano-capsules were optimized by orthogonal experiment,which were listed as the followings:0.70％mass fraction of sodium alginate solution,0.60％mass fraction of gelatin,3.0％mass fraction of tranexamic acid,55℃,pH 4.4,and condensation for 15 min.The thermogra-vimetric analysis(TGA)confirmed the enhanced thermal stability of embedded Tranexamic acid.The prepared nano-capsules of Tranexamic acid exhibited an encapsulation rate of 38.46％and a drug loading of 35.37％.The drug release efficiency was 93.76％in the phosphate buffer solution with pH 6.86 at 7 h.关键词
纳米胶囊/氨甲环酸/海藻酸钠/明胶/复凝聚法Key words
nano-capsules/tranexamic acid/sodium alginate/gelatin/complex coacervation分类
化学化工引用本文复制引用
刘欣,万海伦,栗宇璇,王妍..氨甲环酸纳米胶囊的绿色制备及性能[J].大连工业大学学报,2025,44(5):354-358,5.基金项目
河北省教育厅创新创业教育教学改革研究与实践项目(2023cxcy288). （2023cxcy288）
