国际生殖健康/计划生育杂志2025，Vol.44Issue(5)：393-398,6.DOI:10.12280/gjszjk.20250074
槲皮素对多囊卵巢综合征的潜在治疗作用
The Potential Therapeutic Role of Quercetin in Polycystic Ovary Syndrome
摘要
Abstract
Polycystic ovary syndrome(PCOS),a common multisystem disorder in women of reproductive age,is typically associated with metabolic and reproductive abnormalities.In recent years the attention to the psychological disturbances,adverse pregnancy outcomes,and long-term complications in PCOS patients has been growing.Quercetin(QUE)as a natural flavonoid exhibits the unique therapeutic potential for PCOS management.In terms of metabolic regulation,QUE can improve insulin resistance and modulates glucose/lipid metabolism through multiple pathways.Regarding reproductive endocrinology,QUE can significantly reduce serum androgen level,mitigate follicular atresia and promote follicular maturation,thereby restore normal ovarian function and alleviae ovulatory dysfunction.As for reproductive outcomes,QUE may reduce miscarriage risk via anti-inflammatory,antioxidant and anti-apoptotic properties.Additionally,QUE may have the effects of anti-depressant and anti-cancer,potentially preventing anxiety/depression and endometrial cancer in PCOS patients.While preclinical evidence supports QUE's multifaceted benefits in PCOS,further clinical studies are needed to validate its therapeutic applications.关键词
多囊卵巢综合征/槲皮素/胰岛素抵抗/抑郁/流产/子宫内膜肿瘤Key words
Polycystic ovary syndrome/Quercetin/Insulin resistance/Depression/Abortion/Endometrial neoplasms引用本文复制引用
余健楠,高竹薇,葛航,刘洋,石百超,白宇鑫,高敬书,王宇,吴效科..槲皮素对多囊卵巢综合征的潜在治疗作用[J].国际生殖健康/计划生育杂志,2025,44(5):393-398,6.基金项目
黑龙江省卵巢疾病临床医学研究中心(LC2020R009) （LC2020R009）
黑龙江省"头雁"团队-中西医结合妇科特色技术创新团队 （）
中医药循证能力提升项目(国中医药科技中药便函[2023]24号) （国中医药科技中药便函[2023]24号）
黑龙江省中医药学会2022-2024年度青年人才托举工程项目(2022-QNRC1-02) （2022-QNRC1-02）
