临床与病理杂志2025，Vol.45Issue(7)：841-846,6.DOI:10.11817/j.issn.2095-6959.2025.240954
肠球菌生物被膜形成能力与耐药性的相关性
Correlation between biofilm formation and antibiotic resistance in Enterococcus
曹阳 1赵建平1
作者信息
- 1. 内蒙古自治区人民医院临床检验医学中心,呼和浩特 010010
- 折叠
摘要
Abstract
Objective:Enterococcus is an important pathogen in hospital-acquired infections,and its ability to form biofilms is closely associated with chronic infections and therapeutic failure.This study aims to investigate the relationship between biofilm-forming capacity and antibiotic resistance in Enterococcus,providing a theoretical basis for infection control in clinical practice.
Methods:The biofilm-forming ability of 176 Enterococcus isolates was quantitatively assessed using the crystal violet staining method.Antimicrobial susceptibility to various antibiotics was determined by the broth microdilution method.The correlations between biofilm formation and single-drug as well as multi-drug resistance were analyzed.
Results:Among the 176 Enterococcus isolates,160(90.91%)exhibited biofilm-forming ability.The biofilm-forming rate of Enterococcus faecalis was significantly higher than that of Enterococcus faecium(P<0.05).Except for tetracycline resistance,where the proportion of biofilm-forming strains was significantly higher in the resistant group than in the non-resistant group(P<0.05),no statistically significant correlations were observed between biofilm formation and resistance to other antibiotics(all P>0.05).
Conclusion:The relationship between biofilm formation and antibiotic resistance in Enterococcus is complex.When developing treatment and prevention strategies for Enterococcus infections,clinicians should consider the potential clinical impact of biofilm formation on drug resistance.关键词
肠球菌属/耐药性/生物被膜/结晶紫染色法/相关性Key words
Enterococcus/antibiotic resistance/biofilm/crystal violet staining/correlation引用本文复制引用
曹阳,赵建平..肠球菌生物被膜形成能力与耐药性的相关性[J].临床与病理杂志,2025,45(7):841-846,6.
