临床与病理杂志2025，Vol.45Issue(7)：870-878,9.DOI:10.11817/j.issn.2095-6959.2025.250247
DDR1在肿瘤进展中的多通路调控机制及靶向治疗
Multifaceted regulatory mechanisms of DDR1 in tumor progression and advances in targeted therapy research
摘要
Abstract
Discoidin domain receptor 1(DDR1)is a distinctive member of the receptor tyrosine kinases(RTKs)family that interacts specifically with collagens,the major components of the extracellular matrix(ECM),to exert diverse biological functions.DDR1 not only participates in physiological processes such as maintaining tissue homeostasis and regulating cellular differentiation but also plays a crucial role in pathological conditions,including fibrosis,inflammation,and tumorigenesis.It is highly expressed in multiple malignancies,such as hepatocellular carcinoma,pancreatic cancer,glioma,breast cancer,and melanoma,and its overexpression correlates with poor prognosis.DDR1 contributes to tumor progression through several mechanisms:it promotes tumor cell survival,proliferation,and differentiation;remodels the ECM;regulates metabolic reprogramming;and maintains cancer stemness.In addition,DDR1 can mediate immune evasion and exert immunosuppressive effects across various tumor types.Currently,several DDR1-targeted drugs have entered clinical and preclinical research.A comprehensive understanding of DDR1's molecular mechanisms and its involvement in tumor biology,coupled with a global landscape analysis of DDR1-targeted drug development,will provide a foundation for developing precision diagnostic tools and targeted therapeutic strategies.The growing body of research on DDR1 highlights its potential as a novel and promising target for cancer therapy.关键词
盘状结构域受体1/肿瘤微环境/免疫抑制/肿瘤/靶向治疗Key words
discoidin domain receptor 1/tumor microenvironment/immunosuppression/tumor/targeted therapy引用本文复制引用
王玉兰,吕春莉,张巍..DDR1在肿瘤进展中的多通路调控机制及靶向治疗[J].临床与病理杂志,2025,45(7):870-878,9.基金项目
新疆维吾尔自治区自然科学基金(2022D01D72).This work was supported by the Natural Science Foundation of Xinjiang Uygur Autonomous Region,China(2022D01D72). （2022D01D72）
