神经损伤与功能重建2025,Vol.20Issue(10):584-586,620,4.DOI:10.16780/j.cnki.sjssgncj.20240198
中性粒细胞介导的炎症反应在急性缺血性脑卒中的研究进展
Research Advances in Neutrophil-Mediated Inflammatory Responses in Acute Ischemic Stroke
摘要
Abstract
Acute ischemic stroke(AIS)is a prevalent neurological disorder that can lead to severe disability.During its progression,neutrophils play multifaceted roles-they both drive inflammatory responses and contrib-ute to neural tissue repair.This review comprehensively analyzes the characteristics of neutrophils,their func-tions in AIS,the dual impacts of inflammation,as well as existing and emerging therapeutic strategies.The aim is to enhance understanding of the pathological mechanisms underlying AIS,identify potential therapeutic tar-gets,and provide scientific evidence for improving long-term patient outcomes.关键词
缺血性脑卒中/中性粒细胞/炎症反应/神经保护/治疗策略Key words
ischemic stroke/neutrophils/inflammatory responses/neuroprotection/therapeutic strategies分类
医药卫生引用本文复制引用
莫建莉,安红伟..中性粒细胞介导的炎症反应在急性缺血性脑卒中的研究进展[J].神经损伤与功能重建,2025,20(10):584-586,620,4.基金项目
广西省自然科学基金项目(基于IL-37/TAK1/NF-KB信号通路调控小胶质细胞极化探讨通窍活血汤抑制缺血性脑卒中炎症反应的机制,No.2023GXNSFAA026207) (基于IL-37/TAK1/NF-KB信号通路调控小胶质细胞极化探讨通窍活血汤抑制缺血性脑卒中炎症反应的机制,No.2023GXNSFAA026207)
广西中医药大学自然科学研究课题(通窍活血汤通过LncRN AMALAT1调控缺血性脑卒中后血管新生的初步研究,No.2019MS049) (通窍活血汤通过LncRN AMALAT1调控缺血性脑卒中后血管新生的初步研究,No.2019MS049)
广西区卫生健康委自筹基金项目(探索颅内外大动脉粥样硬化性狭窄的Th1/Th2/Th17相关炎性因子的水平变化,No.720210514) (探索颅内外大动脉粥样硬化性狭窄的Th1/Th2/Th17相关炎性因子的水平变化,No.720210514)