神经损伤与功能重建2025，Vol.20Issue(10)：605-609,5.DOI:10.16780/j.cnki.sjssgncj.20240192
微环境因素调控多发性硬化髓鞘再生的作用及机制研究进展
Research Progress on the Role and Mechanism of Microenvironmental Factors in Regulating Remyelination in Multiple Sclerosis
摘要
Abstract
Multiple sclerosis(MS)pathogenesis is complex,and current clinical treatments cannot halt disease progression and have numerous side effects.There is an urgent need to develop new and effective clinical treatments to improve the clinical symptoms and prognosis of MS patients.Remyelination can provide benefits throughout the entire course of MS,making it a highly promising treatment approach for MS.Oligodendrocyte precursor cells,responsible for myelin regeneration in MS,have their regenerative capacity influenced by various microenvironmental factors.This article provides the first review of the impact and mechanisms of microenvironmental factors such as innate immune cells,myelin debris,extracellular matrix,astrocytes,neurons,pericytes and endothelial cells,adaptive immune cells,peripheral circulation,and aging on MS remyelination,aiming to offer references for the prevention and treatment of MS.关键词
多发性硬化/髓鞘再生/少突胶质前体细胞/微环境/小胶质细胞Key words
multiple sclerosis/remyelination/oligodendrocyte precursor cells/microenvironment/microglia分类
医药卫生引用本文复制引用
王晓莉,杨柳,韩冠先..微环境因素调控多发性硬化髓鞘再生的作用及机制研究进展[J].神经损伤与功能重建,2025,20(10):605-609,5.基金项目
河南省医学科技攻关计划联合共建项目(基于网络药理学和代谢组学探讨三七愈凤胶囊干预急性缺血脑卒中的潜在机制,No.LHGJ20230833) （基于网络药理学和代谢组学探讨三七愈凤胶囊干预急性缺血脑卒中的潜在机制,No.LHGJ20230833）
国家中医药管理局全国名老中医药专家传承工作室建设项目(第七批继承工作,No.国中医药人教函[2022]76号) （第七批继承工作,No.国中医药人教函[2022]76号）
