神经损伤与功能重建2025，Vol.20Issue(10)：610-613,4.DOI:10.16780/j.cnki.sjssgncj.20250353
以单纯眼肌功能障碍为主要表现的Miller-Fisher综合征2例
Two Cases of Miller-Fisher Syndrome Manifesting Primarily as Isolated Ophthalmoplegia
摘要
Abstract
Objective:To analyze the clinical features and prognosis of Miller-Fisher Syndrome Manifesting(MFS)with isolated ophthalmoplegia.Methods:We report two cases of MFS presenting with bilateral isolated ophthalmoplegia as the primary clinical manifestation followed by a systematic review of relevant literature.Results:Case 1 involved a 54-year-old female presenting with diplopia and bilateral blepharospasm following infection.Case 2 described a 67-year-old male who developed diplopia without clear triggers,accompanied by unilateral ptosis,dilated pupils with sluggish light reflex,and ocular motility disorders.Both patients tested positive for serum anti-GQ1b IgG antibodies and anti-GT1a IgG antibodies;Intravenous immunoglobulin therapy was administered to both patients,leading to favorable outcomes.By integrating our two new cases with previously reported instances,we identified a total of seven patients manifesting isolated ocular symptoms:five were anti-GQ1b IgG positive,six exhibited external ophthalmoplegia,five had internal ophthalmoplegia,five reported prodromal infections,and all achieved good recovery.Conclusion:Patients with MFS presenting solely with ocular symptoms are exceedingly rare.These cases significantly enhance our understanding of this distinctive clinical entity.关键词
Miller-Fisher综合征/眼睑痉挛/眼肌麻痹/抗GQ1b抗体Key words
Miller Fisher Syndrome/blepharospasm/ophthalmoplegia/Anti-GQ1b antibody分类
医药卫生引用本文复制引用
张宸睿,徐艳,吴双,谢玉,何丹..以单纯眼肌功能障碍为主要表现的Miller-Fisher综合征2例[J].神经损伤与功能重建,2025,20(10):610-613,4.基金项目
武汉大学中南医院科技创新平台支撑项目(低剂量CD20单抗治疗视神经脊髓炎的临床疗效和安全性研究,No.PTXM2024016) （低剂量CD20单抗治疗视神经脊髓炎的临床疗效和安全性研究,No.PTXM2024016）
