Innate immune cell LXR-β deficiency exacerbates hepatic injury and fibrosis in murine models of primary sclerosing cholangitis
Xiaohui Fang Huiting Su Shan Cao Yulan Liu Jun Xu Yang Zhang Junyao Wang Yu Zhang Ziliang Ke Yiken Lin Fangyuan Cong Feng Zhang Jianhua Zhou
Innate immune cell LXR-β deficiency exacerbates hepatic injury and fibrosis in murine models of primary sclerosing cholangitis
Innate immune cell LXR-β deficiency exacerbates hepatic injury and fibrosis in murine models of primary sclerosing cholangitis
摘要
关键词
Liver X receptor beta(LXR-β)/Primary sclerosing cholangitis(PSC)/Innate immune cells/Liver fibrosis/LXR-β deficiency/Nuclear receptor/Bile acid receptor/DDC-induced PSCKey words
Liver X receptor beta(LXR-β)/Primary sclerosing cholangitis(PSC)/Innate immune cells/Liver fibrosis/LXR-β deficiency/Nuclear receptor/Bile acid receptor/DDC-induced PSC引用本文复制引用
Xiaohui Fang,Huiting Su,Shan Cao,Yulan Liu,Jun Xu,Yang Zhang,Junyao Wang,Yu Zhang,Ziliang Ke,Yiken Lin,Fangyuan Cong,Feng Zhang,Jianhua Zhou..Innate immune cell LXR-β deficiency exacerbates hepatic injury and fibrosis in murine models of primary sclerosing cholangitis[J].肝脏研究（英文）,2025,9(3):239-248,10.基金项目
This work was supported by the National Natural Science Foundation of China(No.82370555 to Jun Xu,and No.82370537 and No.82341228 to Yulan Liu),the Capital Health Research and Development of Special(No.CFH2024-1-4081 to Yulan Liu,and No.CFH2024-4-4089 to Jun Xu),the Beijing Municipal Natural Science Foundation(No.7232196 to Yulan Liu),and Peking Uni-versity People's Hospital Scientific Research Development Funds(No.RDJP2023-22 to Jun Xu and No.RDGS2024-02 to Shan Cao).We extend our sincere appreciation to the personnel of the Insti-tute of Clinical Molecular Biology & Central Laboratory at Peking University People's Hospital for their invaluable technical assistance. （No.82370555 to Jun Xu,and No.82370537 and No.82341228 to Yulan Liu）
