海南医科大学学报2025，Vol.31Issue(19)：1488-1493,6.DOI:10.13210/j.cnki.jhmu.20250103.003
交泰丸对糖尿病脑病小鼠认知功能的影响
Effect of Jiao-tai-wan on cognitive function in mice with diabetic encephalopathy
摘要
Abstract
Objective:To observe the effect of Jiao-tai-wan(JTW)on cognitive function in mice with diabetic encephalopathy.Methods:The db/db mice were randomized into the model group,the high-,medium-,and low-dose groups of JTW,and the metformin group;the db/m mice were set as the blank group,given the drug by stomach gavage once a day for eight consecutive weeks.Water maze test was conducted to detect learning memory function;oral glucose tolerance test and insulin tolerance tests were conducted to detect changes in blood glucose and insulin sensitivity;brain tissue homogenate was prepared to detect the con-tent of MDA and the activity of SOD;and Nissl staining was applied to observe the morphology of neuronal cells in the hippocam-pal tissue area of the brain of the mice.Results:JTW could significantly shorten the swimming exploration distance and evasion la-tency of diabetic encephalopathy modeled mice,meanwhile,it could regulate the blood glucose level and improve the insulin sensi-tivity;it made the MDA content of mouse brain tissue decreased while SOD activity increased;it exerted an improving effect on the histomorphology of neurons in mouse hippocampal tissue.Conclusion:JTW may improve glucose metabolism,inhibit oxida-tive stress,and reduce hippocampal pathological changes in mice,thus enhancing learning and cognitive abilities of mice with dia-betic encephalopathy,and exerting certain efficacy in preventing and controlling diabetic encephalopathy.关键词
交泰丸/糖尿病脑病/认知功能/海马神经元Key words
Jiao-tai-wan/Diabetic encephalopathy/Cognitive function/Hippocampal neurons分类
医药卫生引用本文复制引用
苏妙芳,梁振钰,陈桂敏,王馨晨,张晓庆,李宏英..交泰丸对糖尿病脑病小鼠认知功能的影响[J].海南医科大学学报,2025,31(19):1488-1493,6.基金项目
This study was supported by the National Natural Science Foundation of China(82004246) （82004246）
Natural Science Foundation Project of Hainan Province(822MS069) 国家自然科学基金资助项目(82004246) （822MS069）
海南省自然科学基金资助项目(822MS069) （822MS069）
