中医药导报2025，Vol.31Issue(9)：107-112,6.DOI:10.13862/j.cn43-1446/r.2025.09.018
六味地黄丸汤剂联合针刀治疗绝经后女性膝骨关节炎的临床研究
Clinical Study on Decoction of Liuwei Dihuang Wan(六味地黄丸)Combined with Acupotomy for Knee Osteoarthritis in Postmenopausal Women
摘要
Abstract
Objective:To investigate the clinical efficacy and potential mechanism of decoction of Liuwei Dihuang Wan combined with acupotomy in treating knee osteoarthritis(KOA)in postmenopausal women.Methods:Eighty postmenopausal women with KOA were randomly divided into an acupotomy group(n=40,receiving acupotomy only)and a combination group(n=40,receiving both decoction of Liuwei Dihuang Wan and acupotomy).Visual Analog Scale(VAS)score,Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)score,and modified Kupperman index(for menopausal symptoms)were compared before and after treatment.Levels of matrix metalloproteinase-13(MMP-13),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),estradiol(E2),and follicle-stimulating hormone(FSH)were measured.Synovial thickness and joint effusion range were assessed via ultrasound.Results:After treatment,VAS and WOMAC scores decreased significantly in both groups compared to baseline(P＜0.05).The modified Kupperman score decreased in the combination group(P＜0.05),and all scores were lower in the combination group than in the acupotomy group(P＜0.05).Levels of MMP-13,IL-1β,and TNF-α decreased in both groups post-treatment(P＜0.05),with lower levels in the combination group(P＜0.05).In the combination group,E2 levels increased and FSH levels decreased after treatment(P＜0.05),and these changes were significantly more pronounced compared to the acupotomy group(P＜0.05).Synovial thickness and joint effusion range decreased in both groups(P＜0.05),with greater reduction in the combination group(P＜0.05).The clinical efficacy of the combination group was superior to that of the acupotomy group(P＜0.05).Conclusion:The combination of Liuwei Dihuang Pills and acupotomy can improve knee joint function,alleviate pain,and reduce synovial thickness and joint effusion in postmenopausal women with KOA.Its efficacy is significantly better than acupotomy alone.The mechanism may involve reducing inflammatory factor levels and regulating sex hormone levels.关键词
膝骨关节炎/绝经/六味地黄丸/针刀/临床研究Key words
knee osteoarthritis/menopause/Liuwei Dihuang Wan/acupotomy/clinical study分类
医药卫生引用本文复制引用
张奇,孔丽峰,陈启鹏,柳卓言,吴舒莹,宋寒冰..六味地黄丸汤剂联合针刀治疗绝经后女性膝骨关节炎的临床研究[J].中医药导报,2025,31(9):107-112,6.基金项目
黑龙江省自然科学基金项目(YQ2020H028) （YQ2020H028）
黑龙江省中医药大学研究生创新科研项目(2023YJSCX041) （2023YJSCX041）
