解放军医学杂志2025，Vol.50Issue(9)：1097-1102,6.DOI:10.11855/j.issn.0577-7402.1935.2025.0623
2016-2024年河北省儿童医院呼吸道感染住院患儿肺炎支原体感染的流行病学特征分析
Epidemiological characteristics of Mycoplasma pneumoniae infection among hospitalized children with respiratory tract infections at Children's Hospital of Hebei Province,2016-2024
摘要
Abstract
Objective To investigate the epidemiological characteristics of Mycoplasma pneumoniae(MP)infection among pediatric inpatients with respiratory tract infections(RTIs)at Children's Hospital of Hebei Province,providing evidence for clinical diagnosis and treatment.Methods A retrospective analysis was conducted on 79 546 children hospitalized for RTIs between January 2016 and February 2024.Nasopharyngeal aspirates or deep sputum samples were collected,and polymerase chain reaction(PCR)was used to detect nucleic acids of 13 respiratory pathogens,including MP and adenovirus.The epidemiological trends across different years,seasons,genders,and age groups were analyzed.Results Among the 79 546 enrolled cases(male:47 437,59.6%;female:32 109,40.4%),the MP-positive rate was 17.7%(14 106/79 546),peaking in 2023(28.8%)and reaching the lowest in 2021(7.0%).Except for the period from July 2020 to March 2021 with exceptionally low MP positivity,epidemic peaks consistently occurred between August and February or March of the following year.Seasonal analysis revealed significantly higher MP positivity in autumn and winter compared to spring(P<0.001).Female children exhibited a higher MP-positive rate(20.1%,6444/32 109)than males(16.2%,7662/47 437)(P<0.001).The MP-positive rate increased with age:infancy(3.2%,849/26 741),toddlerhood(9.3%,1935/20 763),preschool(21.2%,3918/18 448),and school-age(54.5%,7404/13 594)(P<0.001).Co-infections with other respiratory pathogens were observed in 37.3%(5264/14 106)of MP-positive cases,with human rhinovirus(HRV)being the most frequent co-pathogen(43.3%,2279/5264 of mixed infections).Conclusion MP is a major pathogen of RTIs in hospitalized children at Children's Hospital of Hebei Province.Infections occur year-round but predominantly in autumn,with higher susceptibility in females and school-age children.Targeted preventive measures should be implemented during peak seasons to mitigate transmission risks.关键词
呼吸道感染/儿童/肺炎支原体/流行病学特征Key words
respiratory tract infection/children/Mycoplasma pneumoniae/epidemiological characteristics分类
医药卫生引用本文复制引用
杜鸿飞,赵梦川,张晓双,周珊珊,黄晶,刘新光,王乐..2016-2024年河北省儿童医院呼吸道感染住院患儿肺炎支原体感染的流行病学特征分析[J].解放军医学杂志,2025,50(9):1097-1102,6.基金项目
This work was supported by the Medical Science Research Project of Hebei Province(20231136) 河北省医学科学研究课题计划资助(20231136) （20231136）
