江西中医药大学学报2025，Vol.37Issue(5)：25-28,4.DOI:10.20140/j.2095-7785.2025.05.08
基于炎癌转化探讨癌瘤外敷方联合定向透药治疗癌痛及对IL-6、TNF-α的影响
Clinical Study on the Treatment of Cancer Pain and Its Effect on IL-6 and TNF-α Levels by External Application Formula of Cancer Combined with TCM Targeted Penetration Based on Inflammatory-Cancer Transformation
摘要
Abstract
Objective:To investigate the efficacy of cancer external application formula combined with traditional Chinese medicine targeted penetration in the treatment of cancer pain and the influence on serum levels of IL-6 and TNF-αbased on inflammatory-cancer transformation.Methods:60 patients meeting the criteria were randomly divided into control group and observation group,with 30 cases in each group.The control group was given oxycodone hydrochloride sustained-release tablets orally,and the observation group was given cancer tumor external application formula combined with TCM targeted penetration on the basis of the control group.The total effective rate,analgesic onset and duration,NRS score,QLQ-C30 quality of life score and serum levels of IL-6 and TNF-α were compared between the two groups.Results:After treatment,the total effective rate of the control group was 86.67%,while the observation group was 93.33%,the difference was statistically significant(P<0.05).The analgesic onset time and duration in the observation group were better than those in the control group(P<0.05).NRS score,QLQ-C30 quality of life score and serum levels of IL-6 and TNF-α in two groups were improved after treatment(P<0.05),and the improvement of observation group was better than control group(P<0.05).Conclusion:Cancer tumor external application formula combined with TCM targeted penetration can effectively shorten the time of drug onset,prolong the duration of drug,effectively relieve the symptoms of abdominal pain,improve the quality of life,and reduce the serum levels of IL-6 and TNF-α.关键词
炎癌转化/中药/癌性疼痛/炎症因子/临床研究Key words
Inflammatory-Cancer Transformation/Traditional Chinese Medicine/Cancer Pain/Inflammatory Cytokines/Clinical Research分类
医药卫生引用本文复制引用
付心柔,李娅娅,李游,杨窑莉,魏国龙,江一平,许嵩..基于炎癌转化探讨癌瘤外敷方联合定向透药治疗癌痛及对IL-6、TNF-α的影响[J].江西中医药大学学报,2025,37(5):25-28,4.基金项目
江西省中医药管理局科技计划项目(2022A051) （2022A051）
江一平全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号). （国中医药人教函[2022]75号）
