江西中医药大学学报2025，Vol.37Issue(5)：77-82,86,7.DOI:10.20140/j.2095-7785.2025.05.19
基于福建黄兔温病气分证发热模型比较不同类型中药注射液的退热效果
Comparison of the Antipyretic Effects of Different Types of Traditional Chinese Medicine Injections Based on a Febrile Model of Wenbing Qifen Syndrome in Fujian Yellow Rabbits
摘要
Abstract
Objective:To compare the antipyretic effects of different types of traditional Chinese medicine(TCM)injections on the febrile model of Wenbing Qifen Syndrome(disease caused by pathogenic heat)in Fujian yellow rabbits.Methods:The febrile model of Wenbing Qifen Syndrome was established in Fujian yellow rabbits by injecting Escherichia coli lipopolysaccharide(LPS).The successfully modeled rabbits were randomly divided into a model group,TCM intervention groups(Qingre Kaitiao group,Qingre Jiedu group,Qing Zangfu Re group,Xinliang Jiebiao group),and a Western medicine intervention group.Twenty minutes after LPS injection,the respective antipyretic agents were administered.The rabbits'clinical signs were observed,and body temperatures were monitored and analyzed.Results:After modeling,the model group showed a temperature increase of more than(2.01±0.41)℃,fever with an increase in temperature of more than 1℃for up to 4.00(3.55,4.45)h,accompanied by lethargy and increased respiratory rate.Comparisons of the TCM intervention groups showed that the Xinliang Jiebiao group had the best antipyretic effect,followed by the Qingre Jiedu group,then the Qingre Kaitiao group,with the Qing Zangfu Re group being the least effective.Among the individual TCM injections,Chuanhuning and Chaihu injections significantly reduced the net temperature increase,with both controlling the temperature rise within 1℃,along with Shuanghuanglian injection.Conclusion:Different types of TCM injections effectively reduced the temperature increase and shortened the fever duration in the Wenbing Qifen Syndrome febrile model in Fujian yellow rabbits.Qingre Jiedu and Xinliang Jiebiao TCM injections demonstrated superior antipyretic effects in this model.关键词
福建黄兔/温病气分证/动物发热模型/中药注射液/退热效果Key words
Fujian Yellow Rabbits/Wenbing Qifen Syndrome/Animal febrile model/Traditional Chinese Medicine Injection/Antipyretic Effect分类
医药卫生引用本文复制引用
周建华,周昀璐,俞春英,刘德强,钱丽萍,吴胜,王训立,黄镇..基于福建黄兔温病气分证发热模型比较不同类型中药注射液的退热效果[J].江西中医药大学学报,2025,37(5):77-82,86,7.基金项目
福建省"雏鹰计划"青年拔尖人才计划项目(闽人社文[2023]142号) （闽人社文[2023]142号）
福建自然科学基金面上项目(2024J01743) （2024J01743）
福建中医药大学青年科技创新培育计划项目(XQC2024003). （XQC2024003）
