检验医学与临床2025，Vol.22Issue(19)：2606-2611,6.DOI:10.3969/j.issn.1672-9455.2025.19.003
血清hs-CRP/PA比值、LIN28B、HDAC2对慢性阻塞性肺疾病急性加重期患者预后不良的预测价值
Predictive value of serum hs-CRP/PA ratio,LIN28B and HDAC2 for poor prognosis in patients with acute exacerbation of chronic obstructive pulmonary disease
摘要
Abstract
Objective To investigate the predictive value of serum high-sensitivity C reactive protein(hs-CRP)/prealbumin(PA)ratio,Lin-28 homolog B(LIN28B)and histone deacetylase 2(HDAC2)for poor prognosis in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 164 AECOPD patients admitted to the hospital from May 2022 to May 2024 were selected as the acute phase group,100 patients with stable COPD were selected as the stable phase group,another 100 healthy people who underwent physical examination in the hospital were selected as the control group.The serum hs-CRP/PA ra-tio,LIN28B and HDAC2 levels were detected and compared among the three groups.AECOPD patients were followed up for 6 months after discharge.According to the prognosis,they were divided into a good prognosis group and a poor prognosis group,and the serum hs-CRP/PA ratio,LIN28B and HDAC2 levels were com-pared between the good prognosis group and the poor prognosis group.Multivariate Logistic regression was used to analyze the influencing factors of poor prognosis in AECOPD patients.Receiver operating characteris-tic(ROC)curve was drawn to analyze the predictive value of serum hs-CRP/PA ratio,LIN28B and HDAC2 for poor prognosis in AECOPD patients.Results The serum hs-CRP/PA ratio and LIN28B level in the acute phase group and the stable phase group were significantly higher than those in the control group,while the se-rum HDAC2 level was significantly lower than that in the control group(P＜0.05).The serum hs-CRP/PA ratio and LIN28B level in the acute phase group were significantly higher than those in the stable phase group,while the serum HDAC2 level was significantly lower than that in the stable phase group,and the differences were statistically significant(P＜0.05).Compared with the good prognosis group,the poor prognosis group had significantly higher serum hs-CRP/PA ratio,LIN28B level,and the proportion of patients with modified British Medical Research Council dyspnea scale(mMRC)grade＞2,while the serum HDAC2 level was sig-nificantly lower(P＜0.05).Multivariate Logistic regression analysis showed that increased serum hs-CRP/PA ratio,increased LIN28B level,and mMRC grade＞2 were risk factors for poor prognosis in patients with AECOPD(P＜0.05).The increased serum HDAC2 level was a protective factor for poor prognosis in AECO-PD patients(P＜0.05).ROC curve analysis showed that the area under the curve(AUC)of the combination of hs-CRP/PA ratio,LIN28B and HDAC2 in predicting poor prognosis of AECOPD patients was 0.857,which was higher than the AUC of the three alone(0.776,0.731,0.694),and the differences were statistically sig-nificant(P＜0.05).Conclusion The levels of serum hs-CRP/PA ratio and LIN28B are increased,and the lev-els of HDAC2 are decreased in AECOPD patients,which are related to the increased risk of poor prognosis in AECOPD patients,and are expected to be potential indicators for the clinical diagnosis and treatment of AE-COPD.关键词
超敏C反应蛋白/前清蛋白/Lin-28同系物B/组蛋白脱乙酰酶2/慢性阻塞性肺疾病急性加重期/预后不良/预测价值Key words
high-sensitivity C reactive protein/prealbumin/Lin-28 homolog B/histone deacetylase 2/acute exacerbation of chronic obstructive pulmonary disease/poor prognosis/predictive value分类
医药卫生引用本文复制引用
范鹏程,崔海涛,刘铠,程秀红..血清hs-CRP/PA比值、LIN28B、HDAC2对慢性阻塞性肺疾病急性加重期患者预后不良的预测价值[J].检验医学与临床,2025,22(19):2606-2611,6.基金项目
山东省优秀中青年科学家科研奖励基金项目(BS2022SW0219). （BS2022SW0219）
