检验医学与临床2025，Vol.22Issue(19)：2612-2617,6.DOI:10.3969/j.issn.1672-9455.2025.19.004
血清sB7-DC、CCL2对发生儿童RMPP的预测价值
Predictive value of serum sB7-DC and CCL2 for the development of RMPP in children
摘要
Abstract
Objective To investigate the predictive value of serum soluble B7-dendritic cell molecules(sB7-DC)and C-C motif chemokine ligand 2(CCL2)for the development of refractory Mycoplasma pneumon-iae pneumonia(RMPP)in children.Methods A total of 80 children with RMPP admitted to the hospital from January 2021 to January 2024 were selected as the RMPP group,80 children with common Mycoplasma pneu-moniae pneumonia admitted to the hospital during the same period were selected as the non-RMPP group ac-cording to a ratio of 1∶1,and 80 healthy children were selected as the control group.According to the progno-sis at 6 months,the children with RMPP were divided into poor prognosis group and good prognosis group.The serum levels of sB7-DC and CCL2 in all subjects were detected by enzyme-linked immunosorbent assay.Multivariate Logistic regression was used to analyze the influencing factors of RMPP in children.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum sB7-DC and CCL2 for the development of RMPP in children.Results The RMPP group and the non-RMPP group had significantly higher serum levels of sB7-DC and CCL2 than the control group(P＜0.05),and the RMPP group had signifi-cantly higher serum levels of sB7-DC and CCL2 than the control group and the non-RMPP group(P＜0.05).Multivariate Logistic regression analysis showed that prolonged duration of fever,high fever,increased levels of C-reactive protein,sB7-DC,and CCL2 were independent risk factors for the development of RMPP in chil-dren(P＜0.05).ROC curve analysis showed that the area under the curve(AUC)of serum sB7-DC and CCL2 combined to predict the occurrence of RMPP in children was 0.878,which was larger than the AUC of serum both alone(0.791,0.795),and the differences were statistically significant(Z=3.275,3.318,both P=0.001).After 6 months of follow-up,22 of 80 children with RMPP had poor prognosis and 58 had good prognosis.The serum levels of sB7-DC and CCL2 in the poor prognosis group were higher than those in the good prognosis group,and the differences were statistically significant(P＜0.05).Conclusion Elevated ser-um levels of sB7-DC and CCL2 are associated with the development and prognosis of RMPP in children.The combination of serum sB7-DC and CCL2 has a high value in predicting the development of RMPP in children.关键词
儿童/难治性肺炎支原体肺炎/可溶性B7-树突状细胞分子/C-C基序趋化因子配体2/预测价值/预后Key words
Children/refractory mycoplasma pneumoniae pneumonia/soluble B7-dendritic cell mole-cules/C-C motif chemokine ligand 2/predictive value/prognosis分类
医药卫生引用本文复制引用
鲁旭,张姣蕊,刘丹,王莉莉,高肖..血清sB7-DC、CCL2对发生儿童RMPP的预测价值[J].检验医学与临床,2025,22(19):2612-2617,6.基金项目
陕西省卫生健康科研基金项目(2020D049). （2020D049）
