检验医学与临床2025，Vol.22Issue(19)：2618-2622,5.DOI:10.3969/j.issn.1672-9455.2025.19.005
变应性鼻炎合并哮喘患者FeNO水平与下气道反应性、气道重塑的关系
Relationship of FeNO level with lower airway responsiveness and airway remodeling in patients with allergic rhinitis and asthma
摘要
Abstract
Objective To investigate the relationship between fractional exhaled nitric oxide(FeNO)level and lower airway responsiveness and airway remodeling in patients with allergic rhinitis(AR)and asthma.Methods A total of 109 patients with AR admitted to the hospital from March 2019 to March 2024 were se-lected as the AR group,101 patients with asthma were selected as the asthma group,105 patients with AR combined with asthma were selected as the AR combined with asthma group,and 100 healthy people who un-derwent physical examination in the hospital were selected as the control group.The levels of FeNO,the posi-tive rate of lower airway responsiveness and airway remodeling indexes[airway wall thickness(T)/airway lu-men diameter(D)ratio,the percentage of total airway wall area to total airway area(WA％)]were measured in each group.The levels of FeNO,the positive rate of lower airway responsiveness,T/D ratio and WA％were compared among the AR group,asthma group,AR combined with asthma group and control group.The levels of FeNO were compared between positive and negative lower airway responsiveness AR patients with asthma.Pearson correlation analysis was used to analyze the correlation between FeNO level and airway remodeling in idicators in AR patients with asthma.Results The level of FeNO,the positive rate of lower airway reactivity,T/D ratio and WA％in AR group,asthma group and AR combined asthma group were higher than those in control group,and the differences were statistically significant(P＜0.05).The level of FeNO,the positive rate of lower airway reactivity,T/D ratio and WA％in the AR combined with asthma group were higher than those in the AR group and the asthma group,and the differences were statistically significant(P＜0.05).The levels of FeNO in moderate and severe patients in AR group,asthma group and AR combined with asthma group were higher than those in mild patients,and the levels of FeNO in severe patients were higher than those in moderate patients,and the differences were statistically significant(P＜0.05).The FeNO level of AR patients with positive lower airway reaction and asthma was higher than that of AR patients with negative lower airway reaction and asthma,and the difference was statistically significant(P＜0.05).Pearson correla-tion analysis showed that FeNO level in AR patients with asthma was positively correlated with T/D ratio and WA％(r=0.525,0.687,P＜0.05).Conclusion FeNO level is increased in AR patients with asthma,and it is closely related to disease severity,lower airway responsiveness and airway remodeling.关键词
变应性鼻炎/哮喘/呼出气一氧化氮/下气道反应性/气道重塑/相关性Key words
allergic rhinitis/asthma/exhaled nitric oxide/lower airway responsiveness/airway re-modeling/correlation分类
医药卫生引用本文复制引用
陈艳,刘妮,孙雅..变应性鼻炎合并哮喘患者FeNO水平与下气道反应性、气道重塑的关系[J].检验医学与临床,2025,22(19):2618-2622,5.基金项目
陕西省自然科学基础研究计划项目(S2022-JC-YB-1686). （S2022-JC-YB-1686）
