摘要
Abstract
Objective To investigate the levels of serum decoy receptor 3(DcR3)and histone deacetylase 2(HDAC2)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and their predictive value for poor prognosis.Methods A total of 100 AECOPD patients admitted to the hospital from May 2022 to May 2023 were selected as the study group.According to the 1-year follow-up outcome,the study group was divided into a poor prognosis group and a good prognosis group.In addition,100 patients with stable COPD admitted to the hospital during the same period were selected as the control group.The serum DcR3 and HDAC2 levels of all subjects were detected by enzyme linked immunosorbent assay.Multivariate Logistic regression was used to analyze the influencing factors of poor prognosis in AECOPD patients.Receiv-er operating characteristic(ROC)curve was used to analyze the predictive value of serum DcR3 and HDAC2 for poor prognosis in AECOPD patients.Results The serum DcR3 level of the study group was significantly higher than that of the control group,and the serum HDAC2 level was significantly lower than that of the control group,and the differences were statistically significant(P＜0.05).Among the AECOPD patients,41 had poor prognosis and 59 had good prognosis after 1 year of follow-up.The poor prognosis group had a sig-nificantly higher proportion of patients with pulmonary heart disease,a significantly higher proportion of pa-tients with mechanical ventilation,and a significantly higher serum DcR3 level than the good prognosis group(P＜0.05),and a significantly lower serum HDAC2 level than the good prognosis group(P＜0.05).Multiva-riate Logistic regression analysis showed that complicated with pulmonary heart disease,mechanical ventila-tion treatment,and increased DcR3 level were risk factors for poor prognosis in AECOPD patients(P＜0.05).The increased HDAC2 level was a protective factor for poor prognosis in AECOPD patients(P＜0.05).ROC curve analysis results showed that the area under the curve(AUC)of serum DcR3 and HDAC2 combined in predicting poor prognosis of AECOPD patients was 0.946,which was greater than the two alone(0.830,0.872),and the differences were statistically significant(Z=3.131,2.566,P=0.002,0.010).Conclu-sion The serum DcR3 level in AECOPD patients is significantly increased,while the serum HDAC2 level is significantly decreased.The combined detection of the two has a higher predictive value for the poor prognosis of AECOPD patients,and may have certain guiding significance for improving the prognosis of patients.关键词
诱骗受体3/组蛋白脱乙酰酶2/慢性阻塞性肺疾病急性加重期/预后不良/预测价值Key words
decoy receptor 3/histone deacetylase 2/acute exacerbation of chronic obstructive pulmo-nary disease/poor prognosis/predictive value分类
医药卫生
