检验医学与临床2025，Vol.22Issue(19)：2628-2632,5.DOI:10.3969/j.issn.1672-9455.2025.19.007
血清IGF-1、CCR2、α-Syn对帕金森病患者发生认知功能障碍的预测价值
Predictive value of IGF-1,CCR2 and α-Syn for cognitive impairment in patients with Parkinson's disease
摘要
Abstract
Objective To investigate the predictive value of insulin-like growth factor-1(IGF-1),chemo-kine receptor 2(CCR2)and α-synuclein(α-Syn)and their predictive value for cognitive impairment in patients with Parkinson's disease(PD).Methods A total of 120 patients with PD admitted to the hospital from Janu-ary 2021 to December 2023 were selected as the PD group.According to the cognitive function of PD patients,the PD group was divided into normal cognitive function group and cognitive dysfunction group.At the same time,and 120 healthy people who underwent physical examination in the hospital were selected as the control group.The serum levels of IGF-1,CCR2 and α-Syn in each group were compared.The Montreal Cognitive As-sessment(MoCA)was used to evaluate the cognitive function of PD patients.Pearson correlation analysis was used to analyze the correlation between serum IGF-1,CCR2,α-Syn levels and MoCA scores in PD patients.Re-ceiver operating characteristic(ROC)curve was used to analyze the predictive value of serum IGF-1,CCR2 and α-Syn for cognitive dysfunction in PD patients.Results The levels of serum CCR2 and α-Syn in PD group were significantly higher than those in control group,and the level of IGF-1 was significantly lower than that in control group(P＜0.05).The serum levels of CCR2 and α-Syn in the cognitive impairment group were sig-nificantly higher than those in the normal cognitive function group,and the IGF-1 level and MoCA score were significantly lower than those in the normal cognitive function group(P＜0.05).Pearson correlation analysis showed that serum IGF-1 level in PD patients was significantly positively correlated with MoCA score(r=0.671,P＜0.001),and CCR2 and α-Syn levels were significantly negatively correlated with MoCA score(r=—0.638,—0.703,P＜0.001).ROC curve analysis showed that the AUC of the combination of IGF-1,CCR2 and α-Syn in predicting cognitive dysfunction in PD patients was 0.911,which was greater than the AUC of the three alone(0.793,0.806,0.828),and the differences were statistically significant(Z=2.197,2.126,1.976,P＜0.05).Conclusion The levels of serum CCR2 and α-Syn in PD patients are increased,and the level of IGF-1 is decreased.The combined detection of serum IGF-1,CCR2 and α-Syn has a high predictive value for cognitive dysfunction in PD patients.关键词
帕金森病/认知功能障碍/胰岛素样生长因子-1/趋化因子受体2/α-突触核蛋白Key words
Parkinson's disease/cognitive impairment/insulin-like growth factor-1/chemokine re-ceptor 2/α-synuclein分类
医药卫生引用本文复制引用
夏虹,刘佳佳,许媛媛..血清IGF-1、CCR2、α-Syn对帕金森病患者发生认知功能障碍的预测价值[J].检验医学与临床,2025,22(19):2628-2632,5.基金项目
江苏省南京市卫生健康委员会指导性科研计划课题(2022112685). （2022112685）
