检验医学与临床2025，Vol.22Issue(19)：2633-2637,2643,6.DOI:10.3969/j.issn.1672-9455.2025.19.008
解毒愈溃汤联合他克莫司治疗糜烂型口腔扁平苔藓的疗效及其对血清IL-17、趋化素水平的影响
Effect of Jiedu Yukui decoction combined with tacrolimus in the treatment of erosive oral lichen planus and its effect on serum IL-17 and Chemerin levels
摘要
Abstract
Objective To investigate the efficacy of Jiedu Yukui decoction combined with tacrolimus in the treatment of erosive oral lichen planus(EOLP)and its effect on serum interleukin(IL)-17 and chemerin lev-els.Methods A total of 86 patients with EOLP admitted to the hospital from March 2022 to April 2024 were selected as the research objects,and were randomly divided into the combination group and the western medi-cine group,with 43 cases in each group.Both groups were treated with tacrolimus ointment,and the combina-tion group was treated with Jiedu Yukui decoction.The clinical efficacy and incidence of adverse reactions were compared between the two groups after treatment.The TCM syndrome score(dry mouth and bitter mouth,o-ral erosion and pain,white stripes,thin white coating),visual analogue scale(VAS)score,physical sign score were compared between the two groups before and after treatment,serum tumor necrosis factor(TNF)-α,IL-17,IL-10,Chemerin were compared between the two groups before and after treatment.Humoral immune in-dexes[immunoglobulin(Ig)G,IgA,IgM]were compared between the two groups before and after treat-ment.The percentage of Th17 and Treg in peripheral blood,and the ratio of Th17/Treg were compared be-tween the two groups before and after treatment.Results The total effective rate of the combination group was significantly higher than that of the western medicine group,and the difference was statistically significant(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).After treatment,the TCM syndrome score,physical sign score,VAS score,the levels of TNF-α,IL-17,Chemerin,Th17,Treg,and Th17/Treg ratio in the two groups were lower than those before treatment,and the TCM syndrome score,physical sign score,VAS score,TNF-α,IL-17,Chemerin,Th17 and Treg levels,and Th17/Treg ratio in the combined treatment group were lower than those in the western medi-cation group,and the differences were statistically significant(P＜0.05).After treatment,the levels of IL-10,IgG,IgM and IgA in the two groups were higher than those before treatment,and the levels of IL-10,IgG,IgM and IgA in the combination group were higher than those in the western medication group,and the differences were statistically significant(P＜0.05).Conclusion Jiedu Yukui decoction combined with tacrolimus in the treatment of EOLP can improve the symptoms of traditional Chinese medicine,relieve pain,reduce inflamma-tory reaction,regulate immune status,and significantly improve the clinical efficacy.关键词
解毒愈溃汤/他克莫司/糜烂型口腔扁平苔藓/趋化素/白细胞介素-17Key words
Jiedu Yukui decoction/tacrolimus/erosive oral lichen planus/chemerin/serum inter-leukin-17分类
医药卫生引用本文复制引用
王丽娜,孔春燕,宋丹丹..解毒愈溃汤联合他克莫司治疗糜烂型口腔扁平苔藓的疗效及其对血清IL-17、趋化素水平的影响[J].检验医学与临床,2025,22(19):2633-2637,2643,6.基金项目
河北省医学科学研究课题(20240896). （20240896）
