检验医学与临床2025，Vol.22Issue(19)：2644-2649,6.DOI:10.3969/j.issn.1672-9455.2025.19.010
中药熏蒸联合透脓散加减治疗肛周脓肿术后创面愈合的疗效及其对肛门功能、炎症因子、生长因子的影响
Effect of traditional Chinese medicine fumigation combined with Toupyosan on wound healing after perianal abscess surgery and its influence on anal function,inflammatory factors and growth factors
摘要
Abstract
Objective To investigate the curative effect of traditional Chinese medicine fumigation com-bined with Toupyosan on wound healing after perianal abscess surgery and its influence on anal function,in-flammatory factors and growth factors.Methods A total of 193 postoperative patients with perianal abscess admitted to the hospital from March 2022 to March 2024 were selected as the research objects,and they were divided into observation group(102 cases)and control group(91 cases)according to whether they were will-ing to use traditional Chinese medicine fuming treatment.Python was further used for propensity score matc-hing analysis,and the confounding factors before treatment were balanced by 1∶1.Finally,60 cases in each group were successfully matched.The control group was treated with addition and reduction of Toupyosan plus conventional cleaning,and the observation group was treated with traditional Chinese medicine fumigation on the basis of the control group.The clinical efficacy,TCM syndrome score,wound related index score,anal function index level,inflammatory factor level,growth factor level,and adverse reactions were compared be-tween the two groups.Results The total effective rate of the observation group was 93.33％,which was higher than 78.33％of the control group,and the difference was statistically significant(P＜0.05).After treatment,the scores of perianal swelling and pain,pus of flesh rot,cold and fever,red tongue and yellow fur in the observation group were lower than those in the control group,and the differences were statistically signifi-cant(P＜0.05).After treatment,the visual analogue scale score,edema score,and exudation score of the ob-servation group were lower than those of the control group,and the wound granulation growth score was high-er than that of the control group,and the differences were statistically significant(P＜0.05).After treat-ment,the anal maximum systolic pressure,anal resting pressure and rectal maximum tolerance threshold in the observation group were higher than those in the control group,and the differences were statistically signif-icant(P＜0.05).After treatment,the levels of interleukin-6,procalcitonin and high-sensitivity C reactive pro-tein in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).After treatment,the levels of vascular endothelial growth factor,fibroblast growth fac-tor and epidermal growth factor in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).There was no significant difference in the incidence of ad-verse reactions between the two groups(P＞0.05).Conclusion Traditional Chinese medicine fumigation combined with Toupyosan has a good effect on perianal abscess after operation,which can promote wound healing,improve the state of TCM score,improve the wound state of patients,increase the pressure level of a-nal muscle group,inhibit the level of inflammatory factors,and improve the level of growth factors,with good safety.关键词
肛周脓肿/透脓散加减/中药熏蒸/创面愈合疗效/肛门功能/炎症因子Key words
perianal abscess/addition and subtraction of Toupyosan/traditional Chinese medicine fu-migation/wound healing efficacy/anal function/inflammatory factor分类
医药卫生引用本文复制引用
张坤,王帅,赵雪芳,郭金玲,冯江敏,尤明辉,王立波,渠兴甫,赵娜,王光娜..中药熏蒸联合透脓散加减治疗肛周脓肿术后创面愈合的疗效及其对肛门功能、炎症因子、生长因子的影响[J].检验医学与临床,2025,22(19):2644-2649,6.基金项目
河北省中医药管理局中医药类科学研究课题计划项目(2023307). （2023307）
