检验医学与临床2025，Vol.22Issue(19)：2660-2664,5.DOI:10.3969/j.issn.1672-9455.2025.19.013
NHR、MHR对溃疡性结肠炎的病情评估及诊断价值
Evaluation and diagnostic value of NHR and MHR in ulcerative colitis
摘要
Abstract
Objective To investigate the value of neutrophil count(N)to high density lipoprotein choles-terol(HDL-C)ratio(NHR)and monocyte count(M)to HDL-C ratio(MHR)in the evaluation and diagnosis of ulcerative colitis(UC).Methods A total of 119 UC patients admitted to the hospital from January 2021 to January 2024 were selected as the UC group.According to the modified Mayo scoring method,119 UC patients were divided into mild activity group,moderate activity group and severe activity group.At the same time,124 healthy people were selected as the control group.Peripheral blood N,M and HDL-C were collected from all subjects,and NHR and MHR were calculated.The differences of N,M,HDL-C,NHR and MHR between the control group and UC group were compared.Receiver operating characteristic(ROC)curve was used to ana-lyze the diagnostic value of N,M,HDL-C,NHR and MHR alone and in combination for UC.Results The N,M,NHR and MHR of the UC group were higher than those of the control group,and the HDL-C level was lower than that of the control group,and the differences were statistically significant(P＜0.05).The N,M,NHR,and MHR of UC patients with different disease activity were as follows:severe active group＞moderate active group＞mild active group,and HDL-C level was as follows:severe active group＜moderate active group＜mild active group,and the differences were statistically significant(P＜0.05).The N,M,NHR and MHR of different types of UC patients were in the order of extensive colitis type＞left hemicolon type＞rectal type,and HDL-C level was in the order of extensive colitis type＜left hemicolon type＜rectal type,and the differences were statistically significant(P＜0.05).ROC curve analysis showed that the area under the curve(AUC)of the combination of N,M,HDL-C,NHR and MHR in the diagnosis of UC was 0.912,which was greater than the AUC of the five indicators alone(0.823,0.789,0.870,0.881,0.870),and the differences were statistically significant(Z=2.673,3.508,2.356,2.164,2.356,P＜0.05).Conclusion NHR and MHR have high diagnostic efficacy in the diagnosis of UC,and the diagnostic efficacy of NHR,MHR combined with N,M,HDL-C in the diagnosis of UC is higher than that of single diagnosis.NHR and MHR can be used as new indicators to evaluate the severity of UC.关键词
溃疡性结肠炎/中性粒细胞计数与高密度脂蛋白胆固醇比值/单核细胞计数与高密度脂蛋白胆固醇比值/活动度Key words
ulcerative colitis/neutrophil count to high density lipoprotein cholesterol ratio/monocyte count to high-density lipoprotein cholesterol ratio/range of motion分类
医药卫生引用本文复制引用
刘慧敏,董筠,高培宇,程迎迎..NHR、MHR对溃疡性结肠炎的病情评估及诊断价值[J].检验医学与临床,2025,22(19):2660-2664,5.基金项目
国家中医临床研究基地(江苏省中医院)开放课题(JD2019SZ07、JD2023SZ05). （江苏省中医院）
