临床肝胆病杂志2025，Vol.41Issue(9)：1729-1736,8.DOI:10.12449/JCH250903
代谢相关脂肪性肝病多器官损伤的病理机制
Pathological mechanism of multi-organ injuries in metabolic dysfunction-associated fatty liver disease
摘要
Abstract
Metabolic dysfunction-associated fatty liver disease(MAFLD)and its progressive form,metabolic dysfunction-associated steatohepatitis(MASH),have emerged as significant types of chronic liver disease worldwide and are closely associated with metabolic syndrome.The liver-extrahepatic organ/tissue axis and the"spill-over effect"of intrahepatic inflammation play pivotal roles in the pathogenesis and progression of MAFLD/MASH,significantly impacting multi-organ metabolic homeostasis and leading to various extrahepatic injuries.These include cardiovascular diseases,sarcopenia,chronic kidney disease,non-alcoholic fatty pancreas disease,polycystic ovary syndrome,hepatocellular carcinoma,and various related solid tumors.There is a notable epidemiological link between MAFLD and the development of both liver cancer and extrahepatic malignancies.The risk of associated tumorigenesis is related to multiple factors,including persistent metabolic disorders,chronic low-grade inflammation,and gut microbiota dysbiosis.Recent research perspectives have shifted from focusing solely on hepatic pathology to recognizing systemic metabolic dysregulation,emphasizing the central role of liver-extrahepatic organ interactions in disease progression.This article aims to explore the pathogenesis of MAFLD/MASH and to review the mechanisms underlying related multi-organ extrahepatic injuries.关键词
代谢相关脂肪性肝病/多器官损伤/病理学Key words
Metabolic Dysfunction-associated Fatty Liver Disease/Multi-organ Injuries/Pathology引用本文复制引用
蒋丽娜,赵景民..代谢相关脂肪性肝病多器官损伤的病理机制[J].临床肝胆病杂志,2025,41(9):1729-1736,8.基金项目
国家重点研发计划(2023YFC2308104,2023YFC2308100) （2023YFC2308104,2023YFC2308100）
北京市医院管理中心临床医学发展专项经费(ZLRK202301) （ZLRK202301）
国家自然科学基金(92159305) National Key R&D Program of China(2023YFC2308104,2023YFC2308100) （92159305）
Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support(ZLRK202301) （ZLRK202301）
National Natural Science Foundation of China(92159305) （92159305）
