代谢相关脂肪性肝病多器官损伤的病理机制OA北大核心

Metabolic dysfunction-associated fatty liver disease(MAFLD)and its progressive form,metabolic dysfunction-associated steatohepatitis(MASH),have emerged as significant types of chronic liver disease worldwide and are closely associated with metabolic syndrome.The liver-extrahepatic organ/tissue axis and the"spill-over effect"of intrahepatic inflammation play pivotal roles in the pathogenesis and progression of MAFLD/MASH,significantly impacting multi-organ metabolic homeostasis and leading to various extrahepatic injuries.These include cardiovascular diseases,sarcopenia,chronic kidney disease,non-alcoholic fatty pancreas disease,polycystic ovary syndrome,hepatocellular carcinoma,and various related solid tumors.There is a notable epidemiological link between MAFLD and the development of both liver cancer and extrahepatic malignancies.The risk of associated tumorigenesis is related to multiple factors,including persistent metabolic disorders,chronic low-grade inflammation,and gut microbiota dysbiosis.Recent research perspectives have shifted from focusing solely on hepatic pathology to recognizing systemic metabolic dysregulation,emphasizing the central role of liver-extrahepatic organ interactions in disease progression.This article aims to explore the pathogenesis of MAFLD/MASH and to review the mechanisms underlying related multi-organ extrahepatic injuries.