临床肝胆病杂志2025，Vol.41Issue(9)：1737-1743,7.DOI:10.12449/JCH250904
多组学技术在代谢相关脂肪性肝病中的潜在应用:从分子机制到血清学标志物
Potential application of multi-omics techniques in metabolic dysfunction-associated fatty liver disease:From molecular mechanisms to serological markers
摘要
Abstract
Metabolic dysfunction-associated fatty liver disease(MAFLD),formerly known as nonalcoholic fatty liver disease(NAFLD),has become a common chronic liver disease worldwide.Currently,the clinical methods for diagnosing liver diseases have limitations such as invasive procedures,insufficient sensitivity,and low diagnostic accuracy,posing challenges to the early identification and precise treatment of MAFLD.In recent years,the rapid development of multi-omics techniques has provided new ideas for the precise diagnosis and treatment of MAFLD.Genomics,metabolomics,lipidomics,microbiomics,and proteomics techniques not only offer new insights into the pathogenesis of MAFLD,but also identify novel biomarkers for disease prediction,diagnosis,and staging.Meanwhile,diagnostic models constructed based on multi-omics data have shown good clinical efficacy and laid an important foundation for the development of noninvasive precise diagnostic tools for MAFLD,and therefore,it is expected to realize the transition from traditional diagnosis and treatment to precision medicine.Although the clinical application value of multi-omics markers in the early diagnosis of MAFLD has been recognized to some extent,there are still challenges in clinical translation,such as the standardization of detection,individual heterogeneity,and cost-effectiveness.关键词
代谢相关脂肪性肝病/生物标记/诊断Key words
Metabolic Dysfunction-associated Fatty Liver Disease/Biomarkers/Diagnosis引用本文复制引用
刘珍妮,龙琪琛,胡敏..多组学技术在代谢相关脂肪性肝病中的潜在应用:从分子机制到血清学标志物[J].临床肝胆病杂志,2025,41(9):1737-1743,7.基金项目
国家自然科学基金(82302586) National Natural Science Foundation of China(82302586) （82302586）
