临床神经病学杂志2025，Vol.38Issue(5)：321-326,6.
轻度海马萎缩对帕金森病患者生活质量的影响及其与认知功能的相关性
Impact of mild hippocampal atrophy on life quality of patients with Parkinson's disease and its correlation with cognitive function
摘要
Abstract
Objective To investigate the impact of mild hippocampal atrophy on life quality of patients with Parkinson's disease(PD)and its correlation with cognitive function.Methods A total of 34 PD patients were recruited from Nanjing Brain Hospital,assessed using the Unified Parkinson's Disease Rating Scale(UPDRS),the Parkinson's Disease Questionnaire(PDQ-39)and the Montreal Cognitive Assessment(MoCA),and underwent MRI scans to measure hippocampal volume.Results Compared with the PD without hippocampal atrophy(PD-nHA)group,the PD with hippocampal atrophy(PD-HA)group showed significantly higher age,PDQ-39 total score,and subscores in physical activity,daily living,cognition,and communication dimensions,along with significantly lower MoCA scores,total hippocampal volume,and bilateral posterior hippocampal volume(all P＜0.05).MoCA subdomain analysis revealed that the PD-HA group exhibited varying degrees of decline across visuospatial/executive function,naming,attention,language,abstraction,delayed recall,and orientation domains,although these differences did not reach statistical significance(all P＞0.05).Total hippocampal volume was negatively correlated with PDQ-39 scores in physical activity,cognition,communication,and total score(r=-0.453,P=0.007;r=-0.364,P=0.034;r=-0.355,P=0.039;r=-0.369,P=0.032),and positively correlated with MoCA total score and three cognitive domains:naming,language,and orientation(r=0.408,P=0.017;r=0.348,P=0.044;r=0.406,P=0.017;r=0.355,P=0.039).The PDQ-39 total score was negatively correlated with the MoCA total score(r=-0.468,P=0.005).Compared with baseline,the PD-HA group showed significantly increased PDQ-39 scores(t=2.378,P=0.039)and significantly decreased right anterior hippocampal gray matter volume(t=-2.751,P=0.022)at the final follow-up,while differences in total hippocampal volume and other hippocampal subregions were not statistically significant(all P＞0.05).MoCA scores showed a declining trend but did not reach statistical significance(t=-0.958,P=0.361).In the PD-nHA group,no statistically significant differences were observed in PDQ-39 scores,MoCA scores,or hippocampal volumes between baseline and final follow-up(all P＞0.05).Conclusions Hippocampal atrophy is closely related to cognitive decline and reduced quality of life in PD patients.Particularly,posterior hippocampal atrophy is more closely related to cognitive dysfunction,and cognitive function serves as a mediator between hippocampal atrophy and quality of life.Early interventions targeting cognitive impairment may help improve the quality of life for PD patients.关键词
帕金森病/海马萎缩/认知功能/生活质量Key words
Parkinson's disease/hippocampal atrophy/cognitive function/life quality分类
医药卫生引用本文复制引用
夏婷婷,邢逸,闫磊,庄娇娇,刘卫国,张睿..轻度海马萎缩对帕金森病患者生活质量的影响及其与认知功能的相关性[J].临床神经病学杂志,2025,38(5):321-326,6.基金项目
国家自然科学基金面上项目(82371268) （82371268）
