临床神经病学杂志2025，Vol.38Issue(5)：339-348,10.
儿童失神癫痫发作终止期功率谱密度和功能连接的脑磁图研究
Magnetoencephalography study of power spectral density and functional connectivity of seizure termination in childhood absence epilepsy
摘要
Abstract
Objective To explore terminal neuromagnetic activity and functional connectivity changes in childhood absence epilepsy(CAE)by multi-frequency magnetoencephalogram(MEG)analysis,and explore the mechanisms of termination and identify biological markers to better understand seizure termination and the recovery of consciousness.Methods This study recruited 20 drug-naive children with CAE and collected MEG data from 30 seizures and interictal periods using a MEG system.Minimum-norm estimation was used to model the distribution of the MEG data,the joint Welch method was used for Power Spectral Density(PSD)analysis,and corrected Amplitude Envelope Correlation was used to assess functional connectivity.Results During seizure termination,the low-frequency power decreased,with beta-band changes occurring first,while high-frequency power remained low and stable.Functional connectivity also shifted,showing transient increased synchrony in the delta band at seizure termination and continual reductions in alpha and beta connectivity.NBS analyses also showed the earliest whole-brain decrease in connectivity in the beta band and a transient enhancement of connectivity in the delta band 1 s before termination.Conclusion This study investigated neuromagnetic changes during seizure termination in CAE using MEG,highlighting the distinct roles of beta-band involvement and delta-band hypersynchronization in CAE termination.关键词
儿童失神癫痫/脑磁图/功能连接/功率谱密度Key words
childhood absence epilepsy/magnetoencephalography/functional connectivity/power spectral density分类
医药卫生引用本文复制引用
李明昊,周欣怡,王英藩,王小姗..儿童失神癫痫发作终止期功率谱密度和功能连接的脑磁图研究[J].临床神经病学杂志,2025,38(5):339-348,10.基金项目
国家自然科学基金项目(82471480) （82471480）
