临床误诊误治2025，Vol.38Issue(20)：60-66,7.DOI:10.3969/j.issn.1002-3429.2025.20.010
老年肌少症患者血清炎性因子水平及与认知功能的相关性分析
Analysis of serum inflammatory factor levels and their correlation with cognitive function in elderly patients with sarcopenia
摘要
Abstract
Objective To analyze the levels of serum inflammatory factors in elderly patients with sarcopenia and their correlation with cognitive function.Methods A total of 120 elderly patients with sarcopenia who were admitted from January 2023 to September 2024 were selected as the observation subjects.According to presence or absence of cognitive dysfunction,the patients were divided into combined cognitive dysfunction group(n=28)and non-combined cognitive dysfunction group(n=92).Clinical data of patients were collected,and the muscle weight,muscle strength and physical activity function of the two groups were compared.The levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)and hypersensitive C reactive protein(hs-CRP)in the serum of patients were detected.Multivariate logistic regression was used to analyze the relationship between serum IL-6,TNF-α,hs-CRP and cognitive dysfunction in elderly patients with sarcopenia.Pearson correlation analysis was used to analyze the correlations of cognitive dysfunction with muscle mass,muscle strength,physical activity function and serum inflammatory factors in elderly patients with sarcopenia.The predictive value of serum IL-6,TNF-α and hs-CRP for cognitive dysfunction in elderly patients with sarcopenia was analyzed by using the receiver operating characteristic(ROC)curve.Results There were significant differences between the two groups in terms of age,educational level,triglycerides,alanine aminotransferase,and γ-glutamyl transferase(P<0.05,P<0.01).The grip strength,chair stand test,limb skeletal muscle mass and limb skeletal muscle mass index in the combined cognitive dysfunction group were all lower than those in the non-combined cognitive dysfunction group(P<0.01).The levels of serum IL-6,TNF-α and hs-CRP in the combined cognitive dysfunction group were significantly higher than those in the non-combined cognitive dysfunction group(P<0.01).After correcting for other confounding factors using multivariate logistic regression analysis,it was found that serum IL-6,TNF-α and hs-CRP were still the influencing factors of cognitive dysfunction in elderly patients with sarcopenia(P<0.01).Pearson correlation analysis showed that the severity of cognitive dysfunction in elderly patients with sarcopenia was positively correlated with serum IL-6,TNF-α,and hs-CRP levels(P<0.05),and negatively correlated with the chair stand test(P<0.05).The results of ROC analysis showed that the combined detection of serum IL-6,TNF-α and hs-CRP had a higher value in predicting senile sarcopenia complicated with cognitive dysfunction than the individual prediction of each index.Conclusion Cognitive dysfunction may be related to sarcopenia,and the combined detection of serum IL-6,TNF-α,and hs-CRP levels has certain predictive value for the occurrence of cognitive dysfunction in elderly patients with sarcopenia.关键词
肌少症/老年人/认知功能障碍/白细胞介素-6/肿瘤坏死因子-α/超敏C反应蛋白/相关性/影响因素分析Key words
sarcopenia/elderly people/cognitive dysfunction/interleukin-6/tumor necrosis factor-α/hypersensitive C reactive protein/correlation/influencing factors引用本文复制引用
孙丽娜,吴玉梅..老年肌少症患者血清炎性因子水平及与认知功能的相关性分析[J].临床误诊误治,2025,38(20):60-66,7.基金项目
上海市加强公共卫生体系建设三年行动计划(2023-2025年)重点学科建设项目(GWVI-11.1-28) （2023-2025年）
华东疗养院科研课题计划(2024007) （2024007）
