临床与实验病理学杂志2025，Vol.41Issue(9)：1163-1168,1174,7.DOI:10.13315/j.cnki.cjcep.2025.09.007
14例中枢神经系统脊索样胶质瘤与脑膜瘤的临床病理及分子遗传学分析
Clinicopathological and molecular genetic analyses of 14 cases of chordoid glioma and chordoid meningioma of the central nervous system
李超 1王映梅 1高晓红 1张红娟 1吴俊峰 1李青 1徐玉乔1
作者信息
- 1. 空军军医大学基础医学院病理学教研室暨第一附属医院病理科,西安 710032
- 折叠
摘要
Abstract
Purpose To investigate the clinicopathological features,diagnostic approaches,and differential diag-nosis of chordoid glioma(CG)and chordoid meningioma(CM)of the central nervous system(CNS).Methods Clinical data from 4 cases of CG and 10 cases of CM were collected.Immunohistochemistry was used to detect the ex-pression of GFAP,EMA,TTF-1,and other markers.Molecular genetic alerations were identified using sequencing techniques and relevant literature was reviewed.Results CG predominantly occurred in the third ventricle but could also arise outside of it.Tumors showed well-defined borders with surrounding tissues.Microscopically,tumor cells were arranged in cords or clusters within a myxoid stroma and expressed GFAP,TTF-1,and other markers.No PRKCA(D463H)mutations were detected in 3 CG cases,however,one case harbored an FLCN ∷ PRKD2 fusion.CM predom-inantly occurred in the supratentorial region but also appeared in the subtentorial area.Histologically,chordoid compo-nents were mixed with classic meningioma features.Chronic inflammatory cell infiltration was noted in the stroma.Tumor cells expressed EMA,PR and SSTR2.One case harbored NF2 mutation and homozygous CDKN2A deletion.Conclusion CG and CM of the CNS shared overlapping morphological characteristics,making histological distinction difficult.Accurate diagnosis required integration of clinical,imaging,immunohistochemical,and molecular pathologi-cal findings.关键词
脊索样胶质瘤/脊索瘤样型脑膜瘤/中枢神经系统/免疫组织化学/基因检测/鉴别诊断Key words
chordoid gliomas/chordoid meningiomas/central nervous system/immunohistochemistry/molecular tes-ting/differential diagnosis分类
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李超,王映梅,高晓红,张红娟,吴俊峰,李青,徐玉乔..14例中枢神经系统脊索样胶质瘤与脑膜瘤的临床病理及分子遗传学分析[J].临床与实验病理学杂志,2025,41(9):1163-1168,1174,7.
