摘要
Abstract
Objective To investigate the efficacy and safety of photodynamic therapy com-bined with minocycline for severe acne.Methods One hundred patients with severe acne were enrolled from the dermatology outpatient department of The First Affiliated Hospital of Dali Univer-sity between January 2020 and June 2021.Participants were randomly assigned to either a study group(n=50)or a control group(n=50).The control group received treatment with minocy-cline and adapalene gel.The study group received 5-aminolevulinic acid photodynamic therapy(5-ALA-PDT)in addition to the standard regimen given to the control group.The two groups were compared in terms of clinical efficacy,course of treatment,safety,and recurrence rates.Results A total of 48 patients in the treatment group and 49 patients in the control group completed the study.At weeks 2,4,and 6,the total effective rates in the study group were significantly higher than those in the control group(58.33％vs.30.61％,95.83％vs.77.55％,and 97.92％vs.83.67％,respectively.P＜0.05 for all).GAGS scores of the study group were significantly lower than those of the control group after 4 and 6 weeks of treatment(P＜0.05 for both).The treatment duration was significantly shorter in the study group compared to the control group[24(20.75,32.25)days vs.42(25.50,45.00)days,U=1 827.50,P＜0.001].There was no significant difference in the incidence of adverse reactions between the two groups(x2=1.62,P=0.203).Although recurrence rates at 1,3,and 6 months were lower in the study group compared to the control group,the differences were not significant(P＞0.05 for all).Conclusions The combina-tion regimen of photodynamic therapy,minocycline,and adapalene gel demonstrates superior effi-cacy,reduced treatment time,and good safety for severe acne.It can serve as a preferred treat-ment strategy.关键词
重度痤疮/光动力疗法/米诺环素Key words
severe acne/photodynamic therapy/minocycline
