摘要
Abstract
We report two cases of refractory cutaneous warts successfully treated with a combi-nation of superficial radiotherapy and topical 5-fluorouracil cream.Case 1:a 13-year-old girl pres-ented with a 1-year history of periungual papules on both hands,exacerbated over the past 2 months.The patient had previously used multiple topical medications(tretinoin cream,imiquimod cream)and undergone liquid nitrogen cryotherapy,with poor response.Dermatological examina-tion revealed multiple verrucous,hyperkeratotic papules around the nails of both hands,some of which were confluent and fissured.Diagnosis:Refractory cutaneous warts.Patient 2,a 16-year-old boy presented with a papule on the left big toe for one year,which had worsened over the past three months.The patient had previously undergone multiple sessions of cryotherapy with liquid nitrogen and topical medications(salicylic acid patches,imiquimod cream),but with poor effica-cy.Dermatological examination revealed a yellow,verrucous,hyperkeratotic papule approximately 1 cm in diameter on the left big toe,with mild tenderness.Diagnosis:Refractory cutaneous warts.Both patients were treated with superficial X-ray radiotherapy(once weekly)combined with topi-cal 2.5％fluorouracil cream under occlusion once a night.After 4-week treatment,the warts in patient 1 were almost completely resolved,leaving only dark erythema and hyperpigmentation.Pa-tient 2 showed near-complete clearance after a 2-week treatment,with only residual dark erythema and hyperpigmentation.No recurrence was observed in either patient during a 3-month follow-up period.关键词
顽固性皮肤疣/浅层X线放射/氟尿嘧啶乳膏Key words
recalcitrant cutaneous warts/superficial radiotherapy/fluorouracil cream
