南京中医药大学学报2025，Vol.41Issue(9)：1224-1231,8.DOI:10.14148/j.issn.1672-0482.2025.1224
紫萸方治疗肾虚型多囊卵巢综合征不孕的临床研究
Clinical Study on Ziyu Prescription in the Treatment of Polycystic Ovary Syndrome Related Infertility of Kidney Deficiency
摘要
Abstract
OBJECTIVE To observe the clinical efficacy of Ziyu Prescription in the treatment of polycystic ovary syndrome relat-ed infertility of kidney deficiency and its effect on endometrial receptivity.METHODS A total of 120 patients with polycystic ovary syndrome related infertility of kidney deficiency were enrolled and randomly divided into a control group and a treatment group,with 60 cases in each group.After excluding dropout cases and excluded cases,56 cases were completed in each group.The control group was treated with letrozole and placebo,while the treatment group was treated with letrozole and Ziyu Prescription.The treatment course of both groups was 3 menstrual cycles.The clinical pregnancy rate and ultrasound Salle score during the implantation window were the main outcome indicators.The traditional Chinese medicine(TCM)syndrome score and serum estradial(E2),testosterone(T),anti-Müllerian hormone(AMH),luteinizing hormone(LH),follicle-stimulating hormone(FSH),homeostatic model assessment of insulin resistance(HOMA-IR),serum E2 and progesterone(P)levels during the implantation window were used as secondary outcome indica-tors.Multivariate Logistic regression and ROC curve analysis were used to evaluate the effect and predictive ability of ultrasound Salle score on pregnancy outcome.Multiple linear regression was used to evaluate the effect of estrogen and progesterone levels during the implantation window on ultrasound Salle score.RESULTS After treatment,the clinical pregnancy rate and ultrasound Salle score during the implantation window in the treatment group were significantly higher than those in the control group(P＜0.05,P＜0.01).The total TCM syndrome score of the treatment group was significantly lower than that of the control group(P＜0.01);the ser-um T,LH/FSH,and HOMA-IR levels of the treatment group were significantly lower than those of the control group(P＜0.05,P＜0.01);the serum E2 and P levels of the treatment group were significantly higher than those of the control group during the implanta-tion window period(P＜0.01).Multivariate Logistic regression analysis and ROC curve analysis showed that ultrasound Salle score was significantly positively correlated with pregnancy rate and had a high predictive value for pregnancy outcome.Multiple linear regression analysis found that there was a linear relationship between the ultrasound Salle score and E2 and P during the implantation window peri-od,and the P level had a greater impact.CONCLUSION Ziyu Prescription can improve the clinical pregnancy rate of patients with polycystic ovary syndrome related infertility of kidney deficiency,effectively improve their endometrial receptivity,regulate the levels of sex hormones and glucose metabolism,reduce the TCM syndrome score,and improve the reproductive quality of patients.关键词
紫萸方/肾虚证/多囊卵巢综合征/不孕症/子宫内膜容受性/临床妊娠率/超声Salle评分/临床研究Key words
Ziyu Prescription/kidney deficiency syndrome/polycystic ovary syndrome/infertility/endometrial receptivity/clinical pregnancy rate/ultrasound Salle score/clinical research分类
医药卫生引用本文复制引用
陆齐天,周一辰,杨冰祎,曾薇薇,陈欣敏,殷岫绮..紫萸方治疗肾虚型多囊卵巢综合征不孕的临床研究[J].南京中医药大学学报,2025,41(9):1224-1231,8.基金项目
上海市卫生健康委员会中医药科研项目(2020LQ009) （2020LQ009）
上海市卫生健康委员会科研项目(20214Y0383) （20214Y0383）
上海中医药大学附属曙光医院"四明临床研究专项"(SGKJLC-202001) （SGKJLC-202001）
