日用化学品科学2025，Vol.48Issue(10)：41-47,60,8.DOI:10.3969/j.issn.1006-7264.2025.10.008
基于共培养模型对不同成分美白与屏障保护作用对比研究
A comparative study on the whitening and barrier-protective effects of different ingredients using a co-culture model
张嘉雯 1陆韫青 1张俊芬 1赵玥 1赵晓 1谢阿贵1
作者信息
- 1. 片仔癀(上海)生物科技研发有限公司,上海 200233
- 折叠
摘要
Abstract
This study compared the whitening and barrier-protective effects of various ingredients.An A375(human melanoma)and HaCaT(human keratinocyte)co-culture model was established to simulate the epidermal melanin unit and to assess the impact of different ingredients on melanin content and the expression of barrier proteins,Filaggrin(FLG)and Loricrin(LOR).Results showed that chemical whitening agents such as hydroquinone and phenylethyl resorcinol,exhibited significant melanin-inhibitory effects at low concentrations but tended to downregulate FLG and LOR expression.In contrast,niacinamide and tranexamic acid demonstrated both melanin inhibition and upregulation of barrier proteins.Notably,Panax notoginseng total saponins displayed good safety,strongly inhibited melanin production,and upregulated FLG expression by 96.74%,outperforming niacinamide and tranexamic acid.These results highlight the dual efficacy of Panax notoginseng total saponins in skin whitening and barrier repair,emphasizing the multi-target regulatory potential of plant-based ingredients and offering a promising strategy for developing scientifically effective and skin-friendly whitening products.关键词
共培养模型/化学美白剂/三七总皂苷/细胞存活率/黑色素含量/屏障蛋白Key words
co-culture model/chemical whitening agents/Panax notoginseng total saponins/cell survival rate/melanin content/barrier proteins分类
化学化工引用本文复制引用
张嘉雯,陆韫青,张俊芬,赵玥,赵晓,谢阿贵..基于共培养模型对不同成分美白与屏障保护作用对比研究[J].日用化学品科学,2025,48(10):41-47,60,8.
