陕西中医2025，Vol.46Issue(10)：1351-1355,5.DOI:10.3969/j.issn.1000-7369.2025.10.010
调脏舒痢方直肠滴入联合美沙拉嗪肠溶片治疗溃疡性结肠炎临床研究
Tiaozang Shuli prescription rectal instillation combined with mesalazine enteric-coated tablets in the treatment of ulcerative colitis
摘要
Abstract
Objective:To investigate the clinical efficacy of rectal administration of Tiaozang Shuli formula com-bined with oral mesalazine enteric-coated tablets in the treatment of ulcerative colitis(UC).Methods:A total of 150 patients diagnosed with the damp-heat syndrome type of ulcerative colitis were enrolled and randomly divided into two groups(n=75 each)using a random number table method.The monotherapy group received mesalazine enteric-coated tablets orally,while the combination group was treated with additional rectal drip of Tiaozang Shuli formula on the basis of the monotherapy group.Clinical efficacy,Traditional Chinese Medicine(TCM)syndrome scores,intesti-nal flora counts,serum inflammatory cytokines[tumor necrosis factor-alpha(TNF-α),interleukin(IL)-10,IL-6,IL-1β],and adverse reactions were compared between the two groups before and after treatment.Results:The total effective rate in the combination group was significantly higher than that in the monotherapy group(P＜0.05).After treatment,the syndrome scores in the combination group showed a significant reduction and were markedly lower than those in the monotherapy group(P＜0.05).The combination group showed significantly higher levels of Bifidobacterium and Lactobacillus,and significantly lower levels of Escherichia coli and Enterococcus compared with the monotherapy group.Additionally,serum levels of TNF-α,IL-1β,and IL-6 were significantly decreased,and IL-10 was significantly increased in the combination group compared to the monotherapy group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Rectal ad-ministration of Tiaozang Shuli formula combined with mesalazine enteric-coated tablets can effectively enhance clini-cal efficacy,relieve symptoms,and reduce inflammatory responses in patients with ulcerative colitis.关键词
溃疡性结肠炎/调脏舒痢方/美沙拉嗪肠溶片/肠道菌群/炎症因子/肿瘤坏死因子-αKey words
Ulcerative colitis/Tiaozang Shuli prescription/Mesalazine enteric-coated tablets/Gut microbiota/Inflammatory factors/Tumor necrosis factor-alpha分类
医药卫生引用本文复制引用
文圆,范艺缤,许莹,刘乐..调脏舒痢方直肠滴入联合美沙拉嗪肠溶片治疗溃疡性结肠炎临床研究[J].陕西中医,2025,46(10):1351-1355,5.基金项目
四川省中医药管理局科学技术研究专项课题(2023MS006) （2023MS006）
